185577

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 823864..824393 Replicon chromosome
Accession NZ_CP067014
Organism Staphylococcus pasteuri strain FDAARGOS_1069

Toxin (Protein)


Gene name mazF Uniprot ID A0A654BHV4
Locus tag I6I26_RS03970 Protein ID WP_017637331.1
Coordinates 824031..824393 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag I6I26_RS03965 Protein ID WP_002451626.1
Coordinates 823864..824034 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I26_RS03940 819681..820154 + 474 WP_029056193.1 PH domain-containing protein -
I6I26_RS03945 820147..821679 + 1533 WP_126567643.1 PH domain-containing protein -
I6I26_RS03950 821666..822160 + 495 WP_046466913.1 PH domain-containing protein -
I6I26_RS03955 822198..822575 + 378 WP_046466914.1 holo-ACP synthase -
I6I26_RS03960 822624..823772 + 1149 WP_046466915.1 alanine racemase -
I6I26_RS03965 823864..824034 + 171 WP_002451626.1 hypothetical protein Antitoxin
I6I26_RS03970 824031..824393 + 363 WP_017637331.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6I26_RS03975 824717..825718 + 1002 Protein_782 PP2C family protein-serine/threonine phosphatase -
I6I26_RS03980 825813..826139 + 327 WP_029056199.1 anti-sigma factor antagonist -
I6I26_RS03985 826141..826620 + 480 WP_017637328.1 anti-sigma B factor RsbW -
I6I26_RS03990 826595..827365 + 771 WP_029056200.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13586.75 Da        Isoelectric Point: 9.9783

>T185577 WP_017637331.1 NZ_CP067014:824031-824393 [Staphylococcus pasteuri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSENKMKEVDYALDISLGLHNFNHPKT

Download         Length: 363 bp

>T185577 NZ_CP088920:c3496480-3496199 [Rhodanobacter denitrificans]
ATGACCATCCAGTCGTTCTGCTGCAAGGATACGCAGGCGCTGTTCGAGCGACGCCGGGTGCGGCGCTTTCTGGTGATCGA
GGCGGCGGCGCGGCGCAAGCTGGAGCTGTTGAATGCGGCGACCCAACTGGACTATCTGCGGGTGCCGCCCGGCAATCGAC
TGGAAGCCTTGGCCGGCGATCGCAAGGGTCAGCACAGCATTCGTGTGAATGACCAGTTCCGGCTGTGCTTCGTGTGGACC
GCCGACGGCCCGGGCCTGGTCGAGATCGTCGATTATCACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT185577 WP_002451626.1 NZ_CP067014:823864-824034 [Staphylococcus pasteuri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT185577 NZ_CP088920:c3496189-3495890 [Rhodanobacter denitrificans]
ATGCCCCGCAAACTGCCACCCATCCACCCCGGCGAGATCCTGCGCGAGGAATACATGCTGCCGCTGGAGCTGTCGTCCAA
CGCGCTGGCCCGCGCCCTCGAAGTCACGCCTGCACGTATCAACGAGATCGTGCGCGAGCGGCGCGGCATCAGCGCCGATA
CCGCGCTGCGGCTGGCGCGCTATTTCGGCAATGACGCGCAGAGCTGGCTGAACCTGCAGCAGCGCTACGACATCGAGTGC
GCGCAGGACAGCATCGGCGGCGCGCTGAGGAAAATCACGCCCTATCAGGCAGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654BHV4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References