Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1654474..1655086 Replicon chromosome
Accession NZ_CP067010
Organism Streptococcus pyogenes strain iGAS376

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag JHX98_RS08435 Protein ID WP_002982731.1
Coordinates 1654751..1655086 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag JHX98_RS08430 Protein ID WP_002988079.1
Coordinates 1654474..1654761 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHX98_RS08405 1649663..1650646 - 984 WP_011889150.1 tagatose-bisphosphate aldolase -
JHX98_RS08410 1650650..1651579 - 930 WP_011889151.1 tagatose-6-phosphate kinase -
JHX98_RS08415 1651627..1652142 - 516 WP_011889152.1 galactose-6-phosphate isomerase subunit LacB -
JHX98_RS08420 1652177..1652605 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
JHX98_RS08425 1653051..1653824 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
JHX98_RS08430 1654474..1654761 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
JHX98_RS08435 1654751..1655086 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHX98_RS08440 1655238..1655708 + 471 WP_021733374.1 site-specific integrase -
JHX98_RS08445 1655671..1656219 + 549 WP_136115776.1 site-specific integrase -
JHX98_RS08450 1656339..1656731 - 393 WP_002982716.1 30S ribosomal protein S9 -
JHX98_RS08455 1656752..1657198 - 447 WP_002982710.1 50S ribosomal protein L13 -
JHX98_RS08460 1657416..1657622 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
JHX98_RS08465 1657619..1658125 - 507 WP_002988070.1 hypothetical protein -
JHX98_RS08470 1658261..1659121 - 861 WP_011889153.1 DegV family protein -
JHX98_RS08475 1659218..1659736 - 519 WP_011889154.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T185575 WP_002982731.1 NZ_CP067010:1654751-1655086 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T185575 NZ_CP088920:1238817-1238993 [Rhodanobacter denitrificans]
ATGAAGTACAGCGAGTTCCAGCGGTGGCTCAGGCAGCAGGGAGTGAGCTTCGAGCCCGGCAAGGGCAGCCACCAGCTGGC
GCGCTACAGAGGCCGGACTTCCGTCTTTCCCTTCCACGGATCGAAAGAGATGCCCGAGCCGCTGCGCAAGAAGATCCTGA
AGGACCTGGGTCTTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT185575 WP_002988079.1 NZ_CP067010:1654474-1654761 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT185575 NZ_CP088920:1239026-1239445 [Rhodanobacter denitrificans]
ATGAAATACCCCGTCAAGCTGACCCGTGCCGATAGCGTGGTGATGGTGACCTGCCCGGACCTGCCGGAGTTTTCCAGCGT
CGGCGACACCGAGGGCGAGGCTCTGCGCGAAGCCGTCGACGGTATCGAAACCACGCTGCAGGCGTACATGCAGGACCGGC
GTGACATTCCGCCGCCGGGCGCGCGCAAGCGCGGCCAGCGGCTGGTGGAGCTGCCGCCGCTGGCGGTGGCCAAGCTCGGT
CTGTACCGGGCCATGCGCGAACAGGGGTTGCGCAAGGCTGACCTGGCCCGCCGGCTCGACGTGCATCTGCCCCAGGTCGA
CCGCCTGCTCGACCTGCGCCACAGCTCGAAGCTGGAACAGGTGGAGGCGGCGCTCAACGCGTTGGGCTACCGGATCGAAC
TGGCGGTGCTGGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References