Detailed information of TA system TA185574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1654395..1655007
• Replicon: chromosome
• Accession: NZ_CP067009
• Organism: Streptococcus pyogenes strain iGAS391

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: JHX97_RS08435
• Protein ID: WP_002982731.1
• Coordinates: 1654672..1655007 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: JHX97_RS08430
• Protein ID: WP_002988079.1
• Coordinates: 1654395..1654682 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHX97_RS08405	1649584..1650567	-	984	WP_011889150.1	tagatose-bisphosphate aldolase	-
JHX97_RS08410	1650571..1651500	-	930	WP_011889151.1	tagatose-6-phosphate kinase	-
JHX97_RS08415	1651548..1652063	-	516	WP_011889152.1	galactose-6-phosphate isomerase subunit LacB	-
JHX97_RS08420	1652098..1652526	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
JHX97_RS08425	1652972..1653745	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
JHX97_RS08430	1654395..1654682	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
JHX97_RS08435	1654672..1655007	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JHX97_RS08440	1655159..1655629	+	471	WP_021733374.1	site-specific integrase	-
JHX97_RS08445	1655592..1656140	+	549	WP_136115776.1	site-specific integrase	-
JHX97_RS08450	1656260..1656652	-	393	WP_002982716.1	30S ribosomal protein S9	-
JHX97_RS08455	1656673..1657119	-	447	WP_002982710.1	50S ribosomal protein L13	-
JHX97_RS08460	1657337..1657543	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
JHX97_RS08465	1657540..1658046	-	507	WP_002988070.1	hypothetical protein	-
JHX97_RS08470	1658182..1659042	-	861	WP_011889153.1	DegV family protein	-
JHX97_RS08475	1659139..1659657	-	519	WP_011889154.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T185574 WP_002982731.1 NZ_CP067009:1654672-1655007 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T185574 NZ_CP088920:722074-722355 [Rhodanobacter denitrificans]
GTGATAAGGAGCTTCGCTGACAAGGAAACCGCGCGACTGTCCGCGACCGGAACAAGCCGGCGGTTTCCGCCGGACATCGT
GCGGCGGGCGCTGAGTCGTCTGAAATATTTGCATCTCGCCACCTGCCCCGAAGATCTGCGCGAGCCGTTTTCCAATCGCC
TGGAAATGTTGAGCGGCAATCGCGCAGGTCAATGGAGTATCCGCATCAACGATCAGTGGCGGCTGTGCTTCCGTTTCGAG
GGCGGCGATGCCTTCGACGTCGAGATCGTCGACTACCATTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT185574 WP_002988079.1 NZ_CP067009:1654395-1654682 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT185574 NZ_CP088920:722368-722673 [Rhodanobacter denitrificans]
ATGTCCATCCCCGCCACCACGAACGGCCTGCCGCCCATTCATCCGGGGGAACTCCTGGAAGAAATCCTGTCCGACCACGG
CATGAGCCAGGCGGCATTTGCCCGGGCGATCGGCGTTTCGCCGATGCGTATTTCGCATGTCATCCGCGAGGAGCGCCCCG
TCACGGCCGAACTTGCCCTGCGCTTTGGCCGCGCCTTCGGCCAGAGCCCGCAGTTCTGGATGAACATGCAGACCGACTAC
GACCTCAAGATCGCCGAGCGTGAACTGAAGGCGAGTTTGCGGAAAGTTCTGCCATTGGCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94