Detailed information of TA system TA185573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1654503..1655115
• Replicon: chromosome
• Accession: NZ_CP067008
• Organism: Streptococcus pyogenes strain iGAS426

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: JCR30_RS08435
• Protein ID: WP_002982731.1
• Coordinates: 1654780..1655115 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: JCR30_RS08430
• Protein ID: WP_002988079.1
• Coordinates: 1654503..1654790 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR30_RS08405	1649692..1650675	-	984	WP_011889150.1	tagatose-bisphosphate aldolase	-
JCR30_RS08410	1650679..1651608	-	930	WP_011889151.1	tagatose-6-phosphate kinase	-
JCR30_RS08415	1651656..1652171	-	516	WP_011889152.1	galactose-6-phosphate isomerase subunit LacB	-
JCR30_RS08420	1652206..1652634	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
JCR30_RS08425	1653080..1653853	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
JCR30_RS08430	1654503..1654790	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
JCR30_RS08435	1654780..1655115	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JCR30_RS08440	1655267..1655737	+	471	WP_021733374.1	site-specific integrase	-
JCR30_RS08445	1655700..1656248	+	549	WP_136115776.1	site-specific integrase	-
JCR30_RS08450	1656368..1656760	-	393	WP_002982716.1	30S ribosomal protein S9	-
JCR30_RS08455	1656781..1657227	-	447	WP_002982710.1	50S ribosomal protein L13	-
JCR30_RS08460	1657445..1657651	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
JCR30_RS08465	1657648..1658154	-	507	WP_002988070.1	hypothetical protein	-
JCR30_RS08470	1658290..1659150	-	861	WP_011889153.1	DegV family protein	-
JCR30_RS08475	1659247..1659765	-	519	WP_011889154.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T185573 WP_002982731.1 NZ_CP067008:1654780-1655115 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T185573 NZ_CP088919:c3544014-3543733 [Rhodanobacter denitrificans]
GTGATAAGGAGCTTCGCTGACAAGGAAACCGCGCGACTGTCCGCGACCGGAACAAGCCGGCGGTTTCCGCCGGACATCGT
GCGGTGGGCGCTGAGTCGTCTGAAATATTTGCATCTCGCCACCTGCCCCGAAGATCTGCGCGAGCCGTTTTCCAATCGCC
TGGAAATGTTGAGCGGCAATCGCGCAGGTCAATGGAGTATCCGCATCAACGATCAGTGGCGGCTGTGCTTCCGTTTCGAG
GGCGGCGATGCCTTCGACGTCGAGATCGTCGACTACCATTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT185573 WP_002988079.1 NZ_CP067008:1654503-1654790 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT185573 NZ_CP088919:c3543720-3543415 [Rhodanobacter denitrificans]
ATGTCCATCCCCGCCACCACGAACGGCCTGCCGCCCATTCATCCGGGGGAGCTCCTGGAAGAAATCCTGTCCGACCACGG
CATGAGCCAGGCGGCATTTGCCCGGGCGATCGGCGTTTCGCCGATGCGTATTTCGCATGTCATCCGCGAGGAGCGCCCCG
TCACGGCCGAACTTGCCCTGCGCTTTGGCCGCGCCTTCGGCCAGAGCCCGCAGTTCTGGATGAACATGCAGACCGACTAC
GACCTCAAGATCGCCGAGCGTGAACTGAAGGCGAGTTTGCGGAAAGTTCTGCCATTGGCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94