Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 307353..307719 Replicon chromosome
Accession NZ_CP067002
Organism Xanthomonas campestris pv. campestris strain 39-3

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH263_RS01245 Protein ID WP_011270059.1
Coordinates 307585..307719 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH263_RS01240 Protein ID WP_011038999.1
Coordinates 307353..307505 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH263_RS01210 (JH263_01210) 302525..303208 - 684 WP_228422659.1 dTMP kinase -
JH263_RS01215 (JH263_01215) 303543..304085 - 543 WP_012439507.1 GTPase -
JH263_RS01220 (JH263_01220) 304082..304999 - 918 WP_014506231.1 hypothetical protein -
JH263_RS01225 (JH263_01225) 305102..305461 - 360 WP_011039002.1 hypothetical protein -
JH263_RS01230 (JH263_01230) 305544..306005 - 462 WP_228422658.1 roadblock/LC7 domain-containing protein -
JH263_RS01235 (JH263_01235) 306319..307242 + 924 WP_274497878.1 arginase -
JH263_RS01240 (JH263_01240) 307353..307505 + 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH263_RS01245 (JH263_01245) 307585..307719 + 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH263_RS01250 (JH263_01250) 307951..308160 + 210 WP_011038998.1 CsbD family protein -
JH263_RS01255 (JH263_01255) 308320..309609 + 1290 WP_029217012.1 tryptophan--tRNA ligase -
JH263_RS01260 (JH263_01260) 309693..310637 + 945 WP_040942012.1 MBL fold metallo-hydrolase -
JH263_RS01265 (JH263_01265) 310802..312454 + 1653 WP_052844768.1 M28 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185565 WP_011270059.1 NZ_CP067002:307585-307719 [Xanthomonas campestris pv. campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185565 NZ_CP088909:c363325-363044 [Rhodococcus qingshengii]
GTGATCGAATCGTTCGCCGACAAGGAGACCGAGCGAGTCTTTCGCCGGCAGTTCTCGAAGAAGCTCCCGCAGGACATTCA
GCGGATCGCGCGCCGGCGTCTGTTGTTGATCGAGGCGGCCACCGACGTCAACGACCTGCGGGTGCCCCCAGGCAACCGCC
TGGAGAAGCTCTCCGGAGACCGGGTGGGCCAGTACAGCGTCCGGATCAACGATCAATACCGCATCTGTTTCATCTGGCGC
GCCACCGCAGCATACGACGTGGAGATCACCGACTACCACTGA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185565 WP_011038999.1 NZ_CP067002:307353-307505 [Xanthomonas campestris pv. campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185565 NZ_CP088909:c362999-362706 [Rhodococcus qingshengii]
ATGACTACAGACCTGAGCCCCATTCACCCCGGCGAGATCCTCCGCGAGGACTTCCTCGAGCCTTTCGGCATCACGCAGAA
CCGCCTGGCCACGATCATCGGTGTGCCGCCGCGGCGGATCAACGAGATCGTGCACGGCAAGCGGTCGATCACCGCAGACA
CCGCGCTGCGGCTGGCCAAGGCGTTCGGCAACAGCGCCCAGTTCTGGCTCAACATCCAGGACCGCTACGAGCTCGACCTT
GCGGCCGACAAGCTAGGCGACACCCTCGCCAAGATCACGCGCCTCTCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References