Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3147421..3148199 Replicon chromosome
Accession NZ_CP067001
Organism Xanthomonas campestris pv. campestris strain 40-2

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH287_RS13870 Protein ID WP_011038220.1
Coordinates 3147708..3148199 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag JH287_RS13865 Protein ID WP_014508712.1
Coordinates 3147421..3147711 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH287_RS13860 (JH287_13855) 3146918..3147345 + 428 Protein_2675 SymE family type I addiction module toxin -
JH287_RS13865 (JH287_13860) 3147421..3147711 + 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
JH287_RS13870 (JH287_13865) 3147708..3148199 + 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH287_RS13875 (JH287_13870) 3148342..3149676 - 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH287_RS13880 (JH287_13875) 3149669..3150346 - 678 WP_003490678.1 response regulator transcription factor -
JH287_RS13885 (JH287_13880) 3150996..3151871 - 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3138539..3157172 18633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185563 WP_011038220.1 NZ_CP067001:3147708-3148199 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185563 NZ_CP088909:160066-160365 [Rhodococcus qingshengii]
ATGCGACCAATTCATGAAGCCAGCCTCGACACAGTTCGTCCGGTCCTCGTACTCACCCGAGAGATGGTCCGTCCACACCT
CGGGACCGTCACGGTAGCGCCCATCACCGGCGAGATCCGAGGACTGTCCACTGAGGTGTCCGTCAGCGCCGCTAACGGAC
TATCCGCCGACGCGGTGGTCAGTTGCGACCACATCACGACCATTCCCGTCAGTGCACTCGGCAACATCATCGGTTATCTT
CTTCCAGCGCAAGAGGAATCACTGTCCATAGCCGTGCGCGCCGCCTTCGATCTCGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT185563 WP_014508712.1 NZ_CP067001:3147421-3147711 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185563 NZ_CP088909:159830-160066 [Rhodococcus qingshengii]
ATGAGCACGCAGATCGCGGTACGACTACCGGACGAGATCGTGGAATTTCTCGACGACGAAGTCAGGGAACATCGCGCCGC
CTCGCGAGCCTCACTAGTGTTGCGCGCTCTCGAACGTGAGCGTCGCCGTCAGATAGCCGCACGAGACGCGGAGATCCTCT
CGGCCGCAACATCCGAACATGATCTGAGCCCCCTCGCTCACCACACCGTGAAACGACAGCCAACAGGCTCGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References