Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4589271..4589637 Replicon chromosome
Accession NZ_CP066999
Organism Xanthomonas campestris pv. campestris strain 29-6

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH292_RS20130 Protein ID WP_011270059.1
Coordinates 4589271..4589405 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH292_RS20135 Protein ID WP_011038999.1
Coordinates 4589485..4589637 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH292_RS20110 (JH292_20040) 4584534..4586186 - 1653 WP_043890286.1 M28 family metallopeptidase -
JH292_RS20115 (JH292_20045) 4586351..4587295 - 945 WP_043890287.1 MBL fold metallo-hydrolase -
JH292_RS20120 (JH292_20050) 4587379..4588668 - 1290 WP_029217012.1 tryptophan--tRNA ligase -
JH292_RS20125 (JH292_20055) 4588828..4589037 - 210 WP_011038998.1 CsbD family protein -
JH292_RS20130 (JH292_20060) 4589271..4589405 - 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH292_RS20135 (JH292_20065) 4589485..4589637 - 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH292_RS20140 (JH292_20070) 4589748..4590671 - 924 WP_040942405.1 arginase -
JH292_RS20145 (JH292_20075) 4590985..4591446 + 462 WP_012439505.1 roadblock/LC7 domain-containing protein -
JH292_RS20150 (JH292_20080) 4591529..4591888 + 360 WP_011039002.1 hypothetical protein -
JH292_RS20155 (JH292_20085) 4591991..4592908 + 918 WP_274496807.1 hypothetical protein -
JH292_RS20160 (JH292_20090) 4592905..4593447 + 543 WP_012439507.1 GTPase -
JH292_RS20165 (JH292_20095) 4593781..4594464 + 684 WP_011039005.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185560 WP_011270059.1 NZ_CP066999:c4589405-4589271 [Xanthomonas campestris pv. campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185560 NZ_CP088902:28886-29368 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185560 WP_011038999.1 NZ_CP066999:c4589637-4589485 [Xanthomonas campestris pv. campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185560 NZ_CP088902:28611-28895 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References