Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1325858..1326636 Replicon chromosome
Accession NZ_CP066999
Organism Xanthomonas campestris pv. campestris strain 29-6

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH292_RS05630 Protein ID WP_011038220.1
Coordinates 1325858..1326349 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag JH292_RS05635 Protein ID WP_014508712.1
Coordinates 1326346..1326636 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH292_RS05615 (JH292_05590) 1322186..1323061 + 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -
JH292_RS05620 (JH292_05595) 1323711..1324388 + 678 WP_003490678.1 response regulator transcription factor -
JH292_RS05625 (JH292_05600) 1324381..1325715 + 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH292_RS05630 (JH292_05605) 1325858..1326349 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH292_RS05635 (JH292_05610) 1326346..1326636 - 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
JH292_RS05640 (JH292_05615) 1326712..1327139 - 428 Protein_1089 SymE family type I addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1316885..1335446 18561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185559 WP_011038220.1 NZ_CP066999:c1326349-1325858 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185559 NZ_CP088902:14789-15121 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT185559 WP_014508712.1 NZ_CP066999:c1326636-1326346 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185559 NZ_CP088902:14531-14788 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References