Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4671212..4671578 Replicon chromosome
Accession NZ_CP066995
Organism Xanthomonas campestris pv. campestris strain 33-4

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH297_RS20405 Protein ID WP_011270059.1
Coordinates 4671212..4671346 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH297_RS20410 Protein ID WP_011038999.1
Coordinates 4671426..4671578 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH297_RS20385 (JH297_20320) 4666477..4668129 - 1653 WP_274498596.1 M28 family metallopeptidase -
JH297_RS20390 (JH297_20325) 4668294..4669238 - 945 WP_040942012.1 MBL fold metallo-hydrolase -
JH297_RS20395 (JH297_20330) 4669322..4670611 - 1290 WP_029217012.1 tryptophan--tRNA ligase -
JH297_RS20400 (JH297_20335) 4670771..4670980 - 210 WP_011038998.1 CsbD family protein -
JH297_RS20405 (JH297_20340) 4671212..4671346 - 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH297_RS20410 (JH297_20345) 4671426..4671578 - 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH297_RS20415 (JH297_20350) 4671689..4672612 - 924 WP_274497878.1 arginase -
JH297_RS20420 (JH297_20355) 4672926..4673387 + 462 WP_228422658.1 roadblock/LC7 domain-containing protein -
JH297_RS20425 (JH297_20360) 4673470..4673829 + 360 WP_011039002.1 hypothetical protein -
JH297_RS20430 (JH297_20365) 4673932..4674849 + 918 WP_014506231.1 hypothetical protein -
JH297_RS20435 (JH297_20370) 4674846..4675388 + 543 WP_012439507.1 GTPase -
JH297_RS20440 (JH297_20375) 4675723..4676406 + 684 WP_228422659.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185553 WP_011270059.1 NZ_CP066995:c4671346-4671212 [Xanthomonas campestris pv. campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185553 NZ_CP088901:3521879-3522097 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185553 WP_011038999.1 NZ_CP066995:c4671578-4671426 [Xanthomonas campestris pv. campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185553 NZ_CP088901:3521477-3521851 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References