Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3777519..3778297 Replicon chromosome
Accession NZ_CP066995
Organism Xanthomonas campestris pv. campestris strain 33-4

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH297_RS16610 Protein ID WP_011038220.1
Coordinates 3777806..3778297 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag JH297_RS16605 Protein ID WP_011038219.1
Coordinates 3777519..3777809 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH297_RS16580 (JH297_16545) 3772598..3773800 + 1203 WP_227971345.1 type II secretion system F family protein -
JH297_RS16585 (JH297_16550) 3773807..3774670 + 864 WP_129588889.1 A24 family peptidase -
JH297_RS16590 (JH297_16555) 3774684..3775307 + 624 WP_040940796.1 dephospho-CoA kinase -
JH297_RS16595 (JH297_16560) 3775912..3777020 + 1109 WP_129588887.1 IS3 family transposase -
JH297_RS16600 (JH297_16565) 3777043..3777444 + 402 WP_040940795.1 SymE family type I addiction module toxin -
JH297_RS16605 (JH297_16570) 3777519..3777809 + 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
JH297_RS16610 (JH297_16575) 3777806..3778297 + 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH297_RS16615 (JH297_16580) 3778440..3779774 - 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH297_RS16620 (JH297_16585) 3779767..3780444 - 678 WP_003490678.1 response regulator transcription factor -
JH297_RS16625 (JH297_16590) 3780475..3780948 - 474 WP_012437597.1 hypothetical protein -
JH297_RS16630 (JH297_16595) 3781171..3782046 - 876 WP_016945000.1 30S ribosomal protein S6--L-glutamate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185552 WP_011038220.1 NZ_CP066995:3777806-3778297 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185552 NZ_CP088901:2101599-2101702 [Salmonella enterica subsp. enterica serovar Muenchen]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT185552 WP_011038219.1 NZ_CP066995:3777519-3777809 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185552 NZ_CP088901:c2101704-2101559 [Salmonella enterica subsp. enterica serovar Muenchen]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References