Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1317070..1317848 Replicon chromosome
Accession NZ_CP066986
Organism Xanthomonas campestris pv. campestris strain 15-1

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH296_RS05575 Protein ID WP_011038220.1
Coordinates 1317070..1317561 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag JH296_RS05580 Protein ID WP_014508712.1
Coordinates 1317558..1317848 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH296_RS05560 (JH296_05550) 1313398..1314273 + 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -
JH296_RS05565 (JH296_05555) 1314923..1315600 + 678 WP_003490678.1 response regulator transcription factor -
JH296_RS05570 (JH296_05560) 1315593..1316927 + 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH296_RS05575 (JH296_05565) 1317070..1317561 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH296_RS05580 (JH296_05570) 1317558..1317848 - 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
JH296_RS05585 (JH296_05575) 1317924..1318351 - 428 Protein_1077 SymE family type I addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1308097..1326730 18633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185535 WP_011038220.1 NZ_CP066986:c1317561-1317070 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185535 NZ_CP088292:c353529-353242 [Phyllobacterium sp. T1018]
ATGATGACGAAGCTCTATGACTACAATCCTGCCGACGCACTCAAATCTGACGAGGCAATAGAGTTATTTCTTGCCGACGC
ATTTGAAACTGGCGATTCTGCCTACATTGCGAAGGCCATCGGGGTAGTCGCAAGATCGAAGGGCATGGCAACGATCGCAC
GCGAGACTGGATTGTCCCGGGAACAACTTTACCGCTCACTGAGTGAAAGTGGAAACCCTACACTGGCCACAACGATAGCC
GTGTTGAAGGCAGTCGGCTTTCAACTGAGTGGCAAACGGGCGGCTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT185535 WP_014508712.1 NZ_CP066986:c1317848-1317558 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185535 NZ_CP088292:c353821-353510 [Phyllobacterium sp. T1018]
ATGATAGGACTGAAACAGACCTCCGTTTATCGTAAGTGGGAAAGCAAGCTGAAAGACCAGAGGGCGAGGGCGGTCATCGC
TGCCCGCCTCTTCCGCTTGGCCAGTGGGCTTGGGAGCGACATTGCATTTGTAGGTGGTGGCGTAAGCGAACTGAGAATTC
ACTATGGACCGGGATACCGGGTTTATTTCCGGCGTCACGGCGAACAGATTGTCATCCTTCTTTGTGGCGGTGACAAGCAG
ACGCAAGATCGGGACATCCGCGAGGCTCGGCGATTGGCAATAGATTGGAGGGATGATGACGAAGCTCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References