Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3613458..3614236 Replicon chromosome
Accession NZ_CP066985
Organism Xanthomonas campestris pv. campestris strain 25-4

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH294_RS15950 Protein ID WP_011038220.1
Coordinates 3613745..3614236 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag JH294_RS15945 Protein ID WP_014508712.1
Coordinates 3613458..3613748 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH294_RS15940 (JH294_15880) 3612955..3613382 + 428 Protein_3071 SymE family type I addiction module toxin -
JH294_RS15945 (JH294_15885) 3613458..3613748 + 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
JH294_RS15950 (JH294_15890) 3613745..3614236 + 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH294_RS15955 (JH294_15895) 3614379..3615713 - 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH294_RS15960 (JH294_15900) 3615706..3616383 - 678 WP_003490678.1 response regulator transcription factor -
JH294_RS15965 (JH294_15905) 3617033..3617908 - 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3604648..3623209 18561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185534 WP_011038220.1 NZ_CP066985:3613745-3614236 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185534 NZ_CP088292:20585-20998 [Phyllobacterium sp. T1018]
ATGCTCCATATGTTGGATACAGATATTGCGAGCTACATCATCAAGGGTCGCTCGCCGAAAATCGATGAAAAGCTCTCAGA
ATTGCAGCCTTCCGATGTCTGCGTCTCTGCCATCACGAAAGCGGAGCTGCTTTACGGCCTGAAACGGATACCTGAAAACC
ATCGTCTTCATGGTGAAATTTCGCGATTTTTCCAGATTGTTCGCGTCCTGGCCTGGGATGCGGTTGCCGCTGAATATTAT
GCCGGCATTCGTCATCAGCTTGTGTCGACCGGCCAGCCGATTGGCGAACTCGATATGATGATCGCTGCACACTCGATCTC
TGTTGGCGCCGTTCTTGTGAGCAACAATACGCGGCACTATCAAAGGATCAGCGGCGGCTTGGCCCTCGCAAACTGGGCTC
AATTGGAAGTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT185534 WP_014508712.1 NZ_CP066985:3613458-3613748 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185534 NZ_CP088292:20277-20546 [Phyllobacterium sp. T1018]
ATGACCGAAGTGCGCATTGCCAAGCTTTTCAAGAACGGCGCGAGCCAGGCCGTCCGGTTGCCGGCTGATTTTCGCTTCGA
TGGCGACGAAGTCTACGTTTCCCGTGATGACCGCACGGGAGACGTCATTCTTTCGACGCGGCCAGGAGCTCGTGTCTGGG
CCGACTTCTTCGAGTTGAGGAACTCCGTCGAAGTCCCTGATGATTTTATGGGCGAGCGCCCAATGAATGCGTTTCCCGTG
GAGCGTAGCTTCTTTGACGAAAACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References