Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3414712..3415490 Replicon chromosome
Accession NZ_CP066984
Organism Xanthomonas campestris pv. campestris strain 27-10

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH284_RS15115 Protein ID WP_011038220.1
Coordinates 3414999..3415490 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag JH284_RS15110 Protein ID WP_014508712.1
Coordinates 3414712..3415002 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH284_RS15105 (JH284_15055) 3414209..3414636 + 428 Protein_2915 SymE family type I addiction module toxin -
JH284_RS15110 (JH284_15060) 3414712..3415002 + 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
JH284_RS15115 (JH284_15065) 3414999..3415490 + 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH284_RS15120 (JH284_15070) 3415633..3416967 - 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH284_RS15125 (JH284_15075) 3416960..3417637 - 678 WP_003490678.1 response regulator transcription factor -
JH284_RS15130 (JH284_15080) 3418287..3419162 - 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3405902..3424463 18561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185532 WP_011038220.1 NZ_CP066984:3414999-3415490 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185532 NZ_CP088290:86094-86501 [Bradyrhizobium septentrionale]
ATGTATCTAATTGATACCAATGTTGTTTCCGAGGCTCGGCGCGGCTCCCCGCAGGCAACCGGCTGGCTGCGCTCTGTAGA
TCCGGCGAGCGTCCACCTGAGCACCCTCACTCTTGGCGAGATTATGCGCGGCATTGCGCTGAAGCAGAAGTCGGATCCCA
AGGCGGCCGGCCATCTTGCCGAATGGCTGCGCAAGCTGCGCCACGACCATGCCGACCGCATCCTGGCGGTGACCGACCAG
ATCTCCGTCGAGTGGGGTCGCATCGCCGCGATCCGACCGCACGGCGATATCGACGGACTGATCGCCGCAACCGCGATCGT
CCACGACCTCATTATCGTCACCCGCAATGTGGGGGATTTCGAGGATACGGGCGCAACGGTGATCAATCCCTGGGAGACAT
CGGCATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT185532 WP_014508712.1 NZ_CP066984:3414712-3415002 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185532 NZ_CP088290:86613-86867 [Bradyrhizobium septentrionale]
ATGGCGCTGAGCATCAAGGATCCCGAAACCGAAAAACTCGCGCGCACGCTAGCAGAGCGGACAGGGGAAACCATCACCGT
CGCGACCCGGCGCGCGATCGAGGATAGGTTGCGACGGGTCGGGGCCGACGCGACCAAGGCCACGCTGATTGAGGACATGG
AAGCCATTCGGCGCCGCCTCGCTACCCTCCCCGTCCTCGATCCACGCAGCATGGATGACATCCTCGGGTACGACGAAAAC
GGCTTGCCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References