Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3613466..3614244 Replicon chromosome
Accession NZ_CP066982
Organism Xanthomonas campestris pv. campestris strain 27-9

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH271_RS15920 Protein ID WP_011038220.1
Coordinates 3613753..3614244 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag JH271_RS15915 Protein ID WP_014508712.1
Coordinates 3613466..3613756 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH271_RS15910 (JH271_15860) 3612963..3613390 + 428 Protein_3065 SymE family type I addiction module toxin -
JH271_RS15915 (JH271_15865) 3613466..3613756 + 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
JH271_RS15920 (JH271_15870) 3613753..3614244 + 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH271_RS15925 (JH271_15875) 3614387..3615721 - 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH271_RS15930 (JH271_15880) 3615714..3616391 - 678 WP_003490678.1 response regulator transcription factor -
JH271_RS15935 (JH271_15885) 3617041..3617916 - 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3603871..3623217 19346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185528 WP_011038220.1 NZ_CP066982:3613753-3614244 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185528 NZ_CP088288:1798425-1798721 [Bradyrhizobium septentrionale]
TTGAAACTCGTCTGGTCGCGCTTCGCGTTGTCCGATCGCGACGACATTTTCAGCTACATCGAAGCCGAGAATCCCCGCGC
TGCGGTTCATGTCGACGAACAGATCGCCGACGCCGCGCGGCGCCTGCTCGACTTTCCTGACAGTGGCCGGCCCGGGCGTG
TCGCCGGCACGCGCGAGTTGGTCATCCCGCGCACACCTTATATCGCGGCGTACCTGGTCGACGGCGAGACTGGCCGCATC
TTGCGCGTGCTTCACGGCGCGCAGATGTGGACCGACGAACTTACAAATGACGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT185528 WP_014508712.1 NZ_CP066982:3613466-3613756 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185528 NZ_CP088288:1798120-1798428 [Bradyrhizobium septentrionale]
ATGGCTTCGAATGCCCTAGTCCAAACCCGCATCGATGCGGACGTAAAGGAAAAGGCCACCGCGGTTCTGGAAAACATGGG
TCTCACGGTATCCGACGCCGTGCGGATCCTGCTGACACGCACGGCCAACGAGGGGGCGCTTCCACTGGAGCTCGTGAGCA
ACAGCCAAGCTTACGACAGCTGGTTTGGTGAGAAGGTGCGCCATGCGCTGGCGGATACCCGGCCCAATCTCGATGATTCC
GAGGTCGAAGCGCATTTCGCGCAACGCCGCACCGCTGCGCTTCGAAAAGCGGCGGAGCGTAAACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References