Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1315647..1316425 Replicon chromosome
Accession NZ_CP066981
Organism Xanthomonas campestris pv. campestris strain 28-1

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH301_RS05555 Protein ID WP_011038220.1
Coordinates 1315647..1316138 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag JH301_RS05560 Protein ID WP_014508712.1
Coordinates 1316135..1316425 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH301_RS05540 (JH301_05520) 1311975..1312850 + 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -
JH301_RS05545 (JH301_05525) 1313500..1314177 + 678 WP_003490678.1 response regulator transcription factor -
JH301_RS05550 (JH301_05530) 1314170..1315504 + 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
JH301_RS05555 (JH301_05535) 1315647..1316138 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH301_RS05560 (JH301_05540) 1316135..1316425 - 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
JH301_RS05565 (JH301_05545) 1316501..1316928 - 428 Protein_1074 SymE family type I addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1306674..1335047 28373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185525 WP_011038220.1 NZ_CP066981:c1316138-1315647 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185525 NZ_CP088282:3405293-3405616 [Bradyrhizobium quebecense]
ATGTCCTGGAGCGTCGAAATCCTCAACGAGGTCGTCGTGGAAGAGATCGCGGCGCTGCCAGCCGACATGCAGGCGCGTTT
CATCCGCCTTTCGGAGCGCATTTCTGCCGCCGGGCTGGAAAGTCTGGGCGAGCCGCATGTGAAGCATTTGGTCGGCAAGC
TTTGGGAATTGCGATTGACCGGGCGAGATGGAATCGCAAGGGCTCTCTATGTGACGGCCTTCGGCCGGCGCGTTGTGGTC
GTCCGCGCGTTCGTGAAGAAGTCCCAGAAGACGCCACCGGGTGAGATCGAGTTGGCGCTGCGGAGAGCAAAGGAAGTCAC
ATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT185525 WP_014508712.1 NZ_CP066981:c1316425-1316135 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185525 NZ_CP088282:3405613-3405894 [Bradyrhizobium quebecense]
ATGACGATACCGTTCGAAAAGCTCAAGGCGCGCCTGTTGGCCAATCCGAAGGTCCGGGCGGAATACGATGCGCTCGCGCC
TGAATTCGAAATCGCTGCCGAGTTGCTCAAGGCGCGTCAGCGCGCGGGACTGTCGCAGTCCGAGCTGGCGGCCAAGATGG
GCACTAGTCAATCAACCATCGCTCGCCTCGAAAGCGGCCAGACGCTTCCAAGTACCAAGACGTTGTTGCGATTTGCCAAG
GCAACCGGCAGCAAGTTCCAGATCCGGCTCTCAGCCGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References