Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1297916..1298694 Replicon chromosome
Accession NZ_CP066966
Organism Xanthomonas campestris pv. campestris strain 08305

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH275_RS05495 Protein ID WP_011038220.1
Coordinates 1297916..1298407 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag JH275_RS05500 Protein ID WP_011038219.1
Coordinates 1298404..1298694 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH275_RS05480 (JH275_05460) 1294244..1295119 + 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -
JH275_RS05485 (JH275_05465) 1295769..1296446 + 678 WP_003490678.1 response regulator transcription factor -
JH275_RS05490 (JH275_05470) 1296439..1297773 + 1335 WP_019237347.1 HAMP domain-containing sensor histidine kinase -
JH275_RS05495 (JH275_05475) 1297916..1298407 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH275_RS05500 (JH275_05480) 1298404..1298694 - 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
JH275_RS05505 (JH275_05485) 1298769..1299170 - 402 WP_019237348.1 SymE family type I addiction module toxin -
JH275_RS05510 (JH275_05490) 1299702..1300325 - 624 WP_011038217.1 dephospho-CoA kinase -
JH275_RS05515 (JH275_05495) 1300339..1301202 - 864 WP_011038216.1 A24 family peptidase -
JH275_RS05520 (JH275_05500) 1301209..1302465 - 1257 WP_011038215.1 type II secretion system F family protein -
JH275_RS05525 (JH275_05505) 1302792..1303232 + 441 WP_011038214.1 pilin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1247619..1301502 53883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185504 WP_011038220.1 NZ_CP066966:c1298407-1297916 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185504 NZ_CP088271:27366-27515 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT185504 WP_011038219.1 NZ_CP066966:c1298694-1298404 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185504 NZ_CP088271:c27321-27262 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References