Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | EcnAB/- |
| Location | 2163929..2164292 | Replicon | chromosome |
| Accession | NZ_CP066963 | ||
| Organism | Xanthomonas campestris strain 3054 | ||
Toxin (Protein)
| Gene name | EcnB | Uniprot ID | G0CKD4 |
| Locus tag | JH273_RS09745 | Protein ID | WP_011270059.1 |
| Coordinates | 2163929..2164063 (-) | Length | 45 a.a. |
Antitoxin (Protein)
| Gene name | EcnA | Uniprot ID | Q8P3Z2 |
| Locus tag | JH273_RS09750 | Protein ID | WP_011038999.1 |
| Coordinates | 2164140..2164292 (-) | Length | 51 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JH273_RS09725 (JH273_09705) | 2159195..2160847 | - | 1653 | WP_274508612.1 | M28 family metallopeptidase | - |
| JH273_RS09730 (JH273_09710) | 2161012..2161956 | - | 945 | WP_274508494.1 | MBL fold metallo-hydrolase | - |
| JH273_RS09735 (JH273_09715) | 2162040..2163329 | - | 1290 | WP_057673596.1 | tryptophan--tRNA ligase | - |
| JH273_RS09740 (JH273_09720) | 2163489..2163698 | - | 210 | WP_274508495.1 | CsbD family protein | - |
| JH273_RS09745 (JH273_09725) | 2163929..2164063 | - | 135 | WP_011270059.1 | entericidin A/B family lipoprotein | Toxin |
| JH273_RS09750 (JH273_09730) | 2164140..2164292 | - | 153 | WP_011038999.1 | entericidin A/B family lipoprotein | Antitoxin |
| JH273_RS09755 (JH273_09735) | 2164403..2165326 | - | 924 | WP_070694619.1 | arginase | - |
| JH273_RS09760 (JH273_09740) | 2165640..2166101 | + | 462 | WP_012439505.1 | roadblock/LC7 domain-containing protein | - |
| JH273_RS09765 (JH273_09745) | 2166184..2166543 | + | 360 | WP_011039002.1 | hypothetical protein | - |
| JH273_RS09770 (JH273_09750) | 2166646..2167563 | + | 918 | WP_014506231.1 | hypothetical protein | - |
| JH273_RS09775 (JH273_09755) | 2167560..2168102 | + | 543 | WP_076035808.1 | GTPase | - |
| JH273_RS09780 (JH273_09760) | 2168437..2169120 | + | 684 | WP_274339650.1 | dTMP kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 45 a.a. Molecular weight: 4431.27 Da Isoelectric Point: 9.3487
>T185502 WP_011270059.1 NZ_CP066963:c2164063-2163929 [Xanthomonas campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK
Download Length: 135 bp
>T185502 NZ_CP088270:c92443-91973 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 51 a.a. Molecular weight: 5173.15 Da Isoelectric Point: 8.2782
>AT185502 WP_011038999.1 NZ_CP066963:c2164292-2164140 [Xanthomonas campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC
Download Length: 153 bp
>AT185502 NZ_CP088270:c92883-92440 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2XDQ0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q8P3Z2 |