185500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 411344..411707 Replicon chromosome
Accession NZ_CP066961
Organism Xanthomonas campestris pv. incanae strain 5057

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH262_RS01715 Protein ID WP_011270059.1
Coordinates 411573..411707 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH262_RS01710 Protein ID WP_011038999.1
Coordinates 411344..411496 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH262_RS01680 (JH262_01675) 406522..407199 - 678 WP_076035807.1 dTMP kinase -
JH262_RS01685 (JH262_01680) 407534..408076 - 543 WP_057673534.1 GTPase -
JH262_RS01690 (JH262_01685) 408073..408990 - 918 WP_274393097.1 hypothetical protein -
JH262_RS01695 (JH262_01690) 409093..409452 - 360 WP_011039002.1 hypothetical protein -
JH262_RS01700 (JH262_01695) 409535..409996 - 462 WP_042595651.1 roadblock/LC7 domain-containing protein -
JH262_RS01705 (JH262_01700) 410310..411233 + 924 WP_057673597.1 arginase -
JH262_RS01710 (JH262_01705) 411344..411496 + 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH262_RS01715 (JH262_01710) 411573..411707 + 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH262_RS01720 (JH262_01715) 411939..412148 + 210 WP_011038998.1 CsbD family protein -
JH262_RS01725 (JH262_01720) 412308..413597 + 1290 WP_043922084.1 tryptophan--tRNA ligase -
JH262_RS01730 (JH262_01725) 413680..414624 + 945 WP_181921549.1 MBL fold metallo-hydrolase -
JH262_RS01735 (JH262_01730) 414789..416441 + 1653 WP_181921563.1 M28 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185500 WP_011270059.1 NZ_CP066961:411573-411707 [Xanthomonas campestris pv. incanae]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185500 NZ_CP088269:c5299431-5299048 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185500 WP_011038999.1 NZ_CP066961:411344-411496 [Xanthomonas campestris pv. incanae]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185500 NZ_CP088269:c5299673-5299431 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References