185498

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 301079..301442 Replicon chromosome
Accession NZ_CP066959
Organism Xanthomonas campestris pv. incanae strain 4053

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH260_RS01265 Protein ID WP_011270059.1
Coordinates 301308..301442 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH260_RS01260 Protein ID WP_011038999.1
Coordinates 301079..301231 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH260_RS01230 (JH260_01240) 296250..296933 - 684 WP_011039005.1 dTMP kinase -
JH260_RS01235 (JH260_01245) 297268..297810 - 543 WP_076035808.1 GTPase -
JH260_RS01240 (JH260_01250) 297807..298724 - 918 WP_274394748.1 hypothetical protein -
JH260_RS01245 (JH260_01255) 298827..299186 - 360 WP_011039002.1 hypothetical protein -
JH260_RS01250 (JH260_01260) 299269..299730 - 462 WP_042595651.1 roadblock/LC7 domain-containing protein -
JH260_RS01255 (JH260_01265) 300045..300968 + 924 WP_076057526.1 arginase -
JH260_RS01260 (JH260_01270) 301079..301231 + 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH260_RS01265 (JH260_01275) 301308..301442 + 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH260_RS01270 (JH260_01280) 301674..301883 + 210 WP_011038998.1 CsbD family protein -
JH260_RS01275 (JH260_01285) 302043..303332 + 1290 WP_162277243.1 tryptophan--tRNA ligase -
JH260_RS01280 (JH260_01290) 303415..304359 + 945 WP_181921549.1 MBL fold metallo-hydrolase -
JH260_RS01285 (JH260_01295) 304524..306176 + 1653 WP_274395351.1 M28 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185498 WP_011270059.1 NZ_CP066959:301308-301442 [Xanthomonas campestris pv. incanae]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185498 NZ_CP088269:c4819560-4819276 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185498 WP_011038999.1 NZ_CP066959:301079-301231 [Xanthomonas campestris pv. incanae]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185498 NZ_CP088269:c4819792-4819550 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References