Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 432670..433033 Replicon chromosome
Accession NZ_CP066958
Organism Xanthomonas campestris strain 11-19

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH302_RS01815 Protein ID WP_011270059.1
Coordinates 432899..433033 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH302_RS01810 Protein ID WP_011038999.1
Coordinates 432670..432822 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH302_RS01780 (JH302_01755) 427842..428525 - 684 WP_274502292.1 dTMP kinase -
JH302_RS01785 (JH302_01760) 428860..429402 - 543 WP_076035808.1 GTPase -
JH302_RS01790 (JH302_01765) 429399..430316 - 918 WP_274502293.1 hypothetical protein -
JH302_RS01795 (JH302_01770) 430419..430778 - 360 WP_011039002.1 hypothetical protein -
JH302_RS01800 (JH302_01775) 430861..431322 - 462 WP_042595651.1 roadblock/LC7 domain-containing protein -
JH302_RS01805 (JH302_01780) 431636..432559 + 924 WP_103700858.1 arginase -
JH302_RS01810 (JH302_01785) 432670..432822 + 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH302_RS01815 (JH302_01790) 432899..433033 + 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH302_RS01820 (JH302_01795) 433264..433473 + 210 WP_011038998.1 CsbD family protein -
JH302_RS01825 (JH302_01800) 433633..434922 + 1290 WP_274502294.1 tryptophan--tRNA ligase -
JH302_RS01830 (JH302_01805) 435006..435950 + 945 WP_274502295.1 MBL fold metallo-hydrolase -
JH302_RS01835 (JH302_01810) 436114..437766 + 1653 WP_161962238.1 M28 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185496 WP_011270059.1 NZ_CP066958:432899-433033 [Xanthomonas campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185496 NZ_CP088269:c4707537-4707004 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185496 WP_011038999.1 NZ_CP066958:432670-432822 [Xanthomonas campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185496 NZ_CP088269:c4707814-4707548 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References