Detailed information of TA system TA185480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1316420..1317198
• Replicon: chromosome
• Accession: NZ_CP066945
• Organism: Xanthomonas campestris pv. campestris strain 08284

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: Q8P667
• Locus tag: JH306_RS05555
• Protein ID: WP_011038220.1
• Coordinates: 1316420..1316911 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: Q8P668
• Locus tag: JH306_RS05560
• Protein ID: WP_011038219.1
• Coordinates: 1316908..1317198 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JH306_RS05540 (JH306_05515)	1312748..1313623	+	876	WP_016945000.1	30S ribosomal protein S6--L-glutamate ligase	-
JH306_RS05545 (JH306_05520)	1314273..1314950	+	678	WP_003490678.1	response regulator transcription factor	-
JH306_RS05550 (JH306_05525)	1314943..1316277	+	1335	WP_057671653.1	HAMP domain-containing sensor histidine kinase	-
JH306_RS05555 (JH306_05530)	1316420..1316911	-	492	WP_011038220.1	GNAT family N-acetyltransferase	Toxin
JH306_RS05560 (JH306_05535)	1316908..1317198	-	291	WP_011038219.1	DUF1778 domain-containing protein	Antitoxin
JH306_RS05565 (JH306_05540)	1317273..1317674	-	402	WP_040940795.1	SymE family type I addiction module toxin	-
JH306_RS05570 (JH306_05545)	1318206..1318829	-	624	WP_116670565.1	dephospho-CoA kinase	-
JH306_RS05575 (JH306_05550)	1318843..1319706	-	864	WP_116670566.1	A24 family peptidase	-
JH306_RS05580 (JH306_05555)	1319713..1320972	-	1260	WP_116670567.1	type II secretion system F family protein	-
JH306_RS05585 (JH306_05560)	1321326..1321745	+	420	WP_116670568.1	pilin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17638.31 Da
• Isoelectric Point: 8.1192

>T185480 WP_011038220.1 NZ_CP066945:c1316911-1316420 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Nucleotide

• Length: 492 bp

>T185480 NZ_CP066945:c1316911-1316420 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10678.23 Da
• Isoelectric Point: 10.5480

>AT185480 WP_011038219.1 NZ_CP066945:c1317198-1316908 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Nucleotide

• Length: 291 bp

>AT185480 NZ_CP066945:c1317198-1316908 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Structures

Toxin

• AlphaFold DB: Q8P667

Antitoxin

• AlphaFold DB: Q8P668