Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 425956..426319 Replicon chromosome
Accession NZ_CP066943
Organism Xanthomonas campestris pv. campestris strain 12049

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH293_RS01735 Protein ID WP_011270059.1
Coordinates 426185..426319 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH293_RS01730 Protein ID WP_011038999.1
Coordinates 425956..426108 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH293_RS01700 (JH293_01700) 421127..421810 - 684 WP_050911792.1 dTMP kinase -
JH293_RS01705 (JH293_01705) 422146..422688 - 543 WP_068574727.1 GTPase -
JH293_RS01710 (JH293_01710) 422685..423602 - 918 WP_014506231.1 hypothetical protein -
JH293_RS01715 (JH293_01715) 423705..424064 - 360 WP_011039002.1 hypothetical protein -
JH293_RS01720 (JH293_01720) 424147..424608 - 462 WP_011039001.1 roadblock/LC7 domain-containing protein -
JH293_RS01725 (JH293_01725) 424922..425845 + 924 WP_011039000.1 arginase -
JH293_RS01730 (JH293_01730) 425956..426108 + 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH293_RS01735 (JH293_01735) 426185..426319 + 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH293_RS01740 (JH293_01740) 426552..426761 + 210 WP_011038998.1 CsbD family protein -
JH293_RS01745 (JH293_01745) 426921..428210 + 1290 WP_029629069.1 tryptophan--tRNA ligase -
JH293_RS01750 (JH293_01750) 428294..429238 + 945 WP_068574725.1 MBL fold metallo-hydrolase -
JH293_RS01755 (JH293_01755) 429403..431055 + 1653 WP_043877841.1 M28 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185478 WP_011270059.1 NZ_CP066943:426185-426319 [Xanthomonas campestris pv. campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185478 NZ_CP088265:590866-591366 [Leclercia sp. G3L]
ATGTTTTCGCAAACGACTCACTATGATTTAACAGGCTTCAACTGCGGGGAAGATACCCTCAACCGTTTTCTGTGTGAGCA
TCTTGCACGCCAGCACGTTGGGCGCTTGTTACGCGCTTATCTTCTCGTCACCGATGACCCTACGCCTAAAGTGCTGGGCT
ACTATACGTTGTCCGGCAGTTGCTTTGAGAAAGAGACCCTGCCATCAAAAACGCAGCAGCGCAAAGTGCCCTATGTCAAT
GTACCCAGCGTCACGTTAGGGCGCCTCGCAATACACCAGGATCTGCAGGGTCAGGGCTGGGGGATGACGCTGGTAACACA
TTCCATGAAAGTGGTCTGGCTGGCGTCGCAGGCTGTGGGCATTCACGGCATGTTTGTGGATGCGCTCAACGATAAGGCGA
AAGATTTTTATCTGACGCTCGGCTTTATTCCTTTAACGGGTAGCAACGCCGATGCTCTTTTTTATCCCACAAAATCCATT
GAAAAGCTGTTTGCCGAATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185478 WP_011038999.1 NZ_CP066943:425956-426108 [Xanthomonas campestris pv. campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185478 NZ_CP088265:590572-590841 [Leclercia sp. G3L]
ATGCCAGCACTGAAAAAACAGCGCATCGACCTCAGGTTAACTGACGAAGACAAAGATCTGATCGAAGAAGCTGCGGCGAT
GACTAACCAGACAATCACCCAGTTTATGGTTAACAGTGCCTCGGAACGGGCTGCCGAAGTCATTGAGCAGCATCGCCGCC
TGATCCTTAATGAAGATTCGTGGAAACGCGTTATGGATGCACTCGACAACCCGCCAGAGCCCAATGAGAGGCTGAAACGC
GCAGCAAGACGTCTGCAAAACATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References