Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4688584..4688947 Replicon chromosome
Accession NZ_CP066936
Organism Xanthomonas campestris pv. campestris strain 10090

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH310_RS20745 Protein ID WP_011270059.1
Coordinates 4688584..4688718 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH310_RS20750 Protein ID WP_011038999.1
Coordinates 4688795..4688947 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH310_RS20725 (JH310_20665) 4683849..4685501 - 1653 WP_172973909.1 M28 family metallopeptidase -
JH310_RS20730 (JH310_20670) 4685665..4686609 - 945 WP_172973853.1 MBL fold metallo-hydrolase -
JH310_RS20735 (JH310_20675) 4686693..4687982 - 1290 WP_172973854.1 tryptophan--tRNA ligase -
JH310_RS20740 (JH310_20680) 4688142..4688351 - 210 WP_011038998.1 CsbD family protein -
JH310_RS20745 (JH310_20685) 4688584..4688718 - 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH310_RS20750 (JH310_20690) 4688795..4688947 - 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH310_RS20755 (JH310_20695) 4689058..4689981 - 924 Protein_4017 arginase -
JH310_RS20760 (JH310_20700) 4690295..4690756 + 462 WP_011039001.1 roadblock/LC7 domain-containing protein -
JH310_RS20765 (JH310_20705) 4690839..4691198 + 360 WP_011039002.1 hypothetical protein -
JH310_RS20770 (JH310_20710) 4691301..4692218 + 918 WP_011039003.1 hypothetical protein -
JH310_RS20775 (JH310_20715) 4692215..4692757 + 543 WP_011039004.1 GTPase -
JH310_RS20780 (JH310_20720) 4693092..4693775 + 684 WP_011039005.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185472 WP_011270059.1 NZ_CP066936:c4688718-4688584 [Xanthomonas campestris pv. campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185472 NZ_CP088247:5199139-5199408 [Methylorubrum sp. B1-46]
GTGAGGCTGCTCTGGTCCGATCAAGCCTGGGAGGACTACCTTTACTGGCAAACGACCGAGCCGGGCACTTTGAGGCGCCT
CAACGAGCTCATCAAGGATGCTTCCCGTTCGCCCTTCACCGGGCTCGGCAAGCCGGAGCCCTTGAAGGGGAACCTGAAGG
GATGGTGGTCGCGCCGGATCACTGGTTCGCACCGTCTTGTGTATCGCGTTGGCGGGATGGGCACCGAGCAGACCCTCGAG
ATCGCCCAGTGCCGCTGGCACTACGAGTGA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185472 WP_011038999.1 NZ_CP066936:c4688947-4688795 [Xanthomonas campestris pv. campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185472 NZ_CP088247:5198888-5199142 [Methylorubrum sp. B1-46]
ATGGGCTATGTCGGTTACACGGAGTTGCGACGTAACCTGGCCGAGCATCTCGATCGGGTCGAGAGCGATCGGGCGGAGCT
CGTCGTGTCGCGTCGCAATCGCGAGGATCTCGCGATCATTCCTCTCGCCGAGTTGGAGAGCCTGCGCGAGACCCTGCACC
TGCTCGGTACGCCGGCCAATGCGGCCCGTCTGATCGCGGGCGTGCGTCAACTCGATGCGGGCGGAGGAGCGGAGCATTCT
CTGATCGAAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References