Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1323848..1324626 Replicon chromosome
Accession NZ_CP066934
Organism Xanthomonas campestris pv. campestris strain 08290

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag JH256_RS05615 Protein ID WP_011038220.1
Coordinates 1323848..1324339 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag JH256_RS05620 Protein ID WP_011038219.1
Coordinates 1324336..1324626 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH256_RS05600 (JH256_05565) 1320176..1321051 + 876 WP_016945000.1 30S ribosomal protein S6--L-glutamate ligase -
JH256_RS05605 (JH256_05570) 1321701..1322378 + 678 WP_003490678.1 response regulator transcription factor -
JH256_RS05610 (JH256_05575) 1322371..1323705 + 1335 WP_019237347.1 HAMP domain-containing sensor histidine kinase -
JH256_RS05615 (JH256_05580) 1323848..1324339 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
JH256_RS05620 (JH256_05585) 1324336..1324626 - 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
JH256_RS05625 (JH256_05590) 1324701..1325102 - 402 WP_019237348.1 SymE family type I addiction module toxin -
JH256_RS05630 (JH256_05595) 1325634..1326257 - 624 WP_011038217.1 dephospho-CoA kinase -
JH256_RS05635 (JH256_05600) 1326271..1327134 - 864 WP_011038216.1 A24 family peptidase -
JH256_RS05640 (JH256_05605) 1327141..1328397 - 1257 WP_011038215.1 type II secretion system F family protein -
JH256_RS05645 (JH256_05610) 1328724..1329164 + 441 WP_011038214.1 pilin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1119753..1387169 267416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(42-144)

Antitoxin

(1-95)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T185468 WP_011038220.1 NZ_CP066934:c1324339-1323848 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T185468 NZ_CP088247:221465-221968 [Methylorubrum sp. B1-46]
GTGCCCCTATCGGCTCCCGAACCGATCACGGCCGCGCATGACGTCTCACAATTCTCCTGCGGCAAGCCGACGCTCGATCA
CTGGCTGAAAACCCGCGCCCTGTCGAACCAGACGAAGGGCTTTACCGCCGTTCTCGTGGTGCATGAGGCCGGGCGGGTTG
TCGGCTATTACGGTCTGGCGCCGACGGCGGTGGTGCCCGCCGTTCTGCCGCGCGCGGTCCGCACCGGACAGCCGCCCGAT
CCGGTTCCCTGTCTGCTTCTCGGCCAGCTCGCCACGGACGAAGCTTGGGTGGGGCAAGGGATAGGCACCGGTCTCGTCAA
ACATGCGCTCCAGCGCTGCGTGCAAGCAGCCAGCCTGGTCGGCGGACGGGCCTTGATGGTGAATGCCATCGATGACGACG
CTGCACAGTTCTGGCAGCGGCGCGGCTTTTTGCCGACGCACGATGATCCGCTCGTTCTCTTCCGGTCCATCGCGGCGATC
GCTGCCTCGCTGACGCAGGCGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT185468 WP_011038219.1 NZ_CP066934:c1324626-1324336 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT185468 NZ_CP088247:221162-221461 [Methylorubrum sp. B1-46]
ATGGCCAGCACAGCAGAACGCAAGGAATATCCCATCTCGATGCGATTGCCGGAGTCGGATGTCGCGATGATCGATCGAGC
GGCCACGCTGCGGGGTCGCTCGCGCACCGACTTCGTGCGCGACGCCGCCGTGCGCGCTGCCGAGGAAGTGGTCATGGAAC
AAAGCTTCATCCGCATGAGCCCGGAAGGGTTCGCCGGGTTCATGGAGGTTCTGGCCGCCCCCGCAATGCCGGTCCCCGCG
ATGGTAAAGCTGGCCAAGCGTCCGGCGCCCTGGGAACCCGGTTATGAACCGAAGCGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q8P667


Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References