Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4560935..4561301 Replicon chromosome
Accession NZ_CP066932
Organism Xanthomonas campestris pv. raphani strain 576

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH277_RS19680 Protein ID WP_011270059.1
Coordinates 4560935..4561069 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH277_RS19685 Protein ID WP_011038999.1
Coordinates 4561149..4561301 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH277_RS19660 (JH277_19595) 4556202..4557854 - 1653 WP_274299770.1 M28 family metallopeptidase -
JH277_RS19665 (JH277_19600) 4558019..4558963 - 945 WP_274298824.1 MBL fold metallo-hydrolase -
JH277_RS19670 (JH277_19605) 4559046..4560335 - 1290 WP_274298825.1 tryptophan--tRNA ligase -
JH277_RS19675 (JH277_19610) 4560495..4560704 - 210 WP_011038998.1 CsbD family protein -
JH277_RS19680 (JH277_19615) 4560935..4561069 - 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH277_RS19685 (JH277_19620) 4561149..4561301 - 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH277_RS19690 (JH277_19625) 4561412..4562335 - 924 WP_274298826.1 arginase -
JH277_RS19695 (JH277_19630) 4562649..4563110 + 462 WP_228422658.1 roadblock/LC7 domain-containing protein -
JH277_RS19700 (JH277_19635) 4563193..4563552 + 360 WP_011039002.1 hypothetical protein -
JH277_RS19705 (JH277_19640) 4563655..4564572 + 918 WP_014506231.1 hypothetical protein -
JH277_RS19710 (JH277_19645) 4564569..4565111 + 543 WP_076035808.1 GTPase -
JH277_RS19715 (JH277_19650) 4565446..4566129 + 684 WP_011039005.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185465 WP_011270059.1 NZ_CP066932:c4561069-4560935 [Xanthomonas campestris pv. raphani]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185465 NZ_CP088244:c3561261-3560983 [Stenotrophomonas maltophilia]
TTGATACGAACGTACGCAGACAAGGACACGGAACGAATAGCCAGCGGCAAGAAAGTTAAAGCCCTGGCTAATCTGGAAAA
ACAGATTCTACGAAAGCTGGTCTATCTCAACGCTGCGACTTCACTACTTGACCTGAAGGCCCCTCCAGGCAACAGGTTGG
AAGCCCTCAAAGGCGACAGGTCAGGGCAGTACAGCATTCGCATCAATGACCAGTTTCGGATCTGTTTCAAGTGGAAAGAT
GGCGACGTTTACGATGTAGAGATCACCGACTACCACTGA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185465 WP_011038999.1 NZ_CP066932:c4561301-4561149 [Xanthomonas campestris pv. raphani]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185465 NZ_CP088244:c3560839-3560525 [Stenotrophomonas maltophilia]
ATGACACGCGCCAACGCAAAAACTGCTATCGCGCTCCCCGCTATCCATCCGGGAGAAATCCTTTCCGAAGAGTTCCTGGT
CCCGCTGGGCATGTCCGCACGCGCACTGGCCGCCGAGATCAATGTCACCCCGGCCCGCGTTTCTGAGATCATCGCCGGCC
GTCGCGGCATCACCGCCGATACCGCGCTTCGTCTGGGACGCTACTTCGGCACCACGCCACAGCTGTGGTTGAACCTGCAA
ACGCAGTACGACCTGTTGACCGTTAGCGTGGAACTGGCGGATGTGATCGACCACATCAGCCCCAGGGCCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References