Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) EcnAB/-
Location 4521884..4522247 Replicon chromosome
Accession NZ_CP066926
Organism Xanthomonas campestris pv. incanae strain CFBP6690

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH261_RS19430 Protein ID WP_011270059.1
Coordinates 4521884..4522018 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH261_RS19435 Protein ID WP_011038999.1
Coordinates 4522095..4522247 (-) Length 51 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH261_RS19410 (JH261_19410) 4517148..4518800 - 1653 WP_274318722.1 M28 family metallopeptidase -
JH261_RS19415 (JH261_19415) 4518965..4519909 - 945 WP_274317732.1 MBL fold metallo-hydrolase -
JH261_RS19420 (JH261_19420) 4519993..4521282 - 1290 WP_161962176.1 tryptophan--tRNA ligase -
JH261_RS19425 (JH261_19425) 4521443..4521652 - 210 WP_011038998.1 CsbD family protein -
JH261_RS19430 (JH261_19430) 4521884..4522018 - 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH261_RS19435 (JH261_19435) 4522095..4522247 - 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH261_RS19440 (JH261_19440) 4522358..4523281 - 924 WP_274317733.1 arginase -
JH261_RS19445 (JH261_19445) 4523595..4524056 + 462 WP_042595651.1 roadblock/LC7 domain-containing protein -
JH261_RS19450 (JH261_19450) 4524139..4524498 + 360 WP_011039002.1 hypothetical protein -
JH261_RS19455 (JH261_19455) 4524591..4525508 + 918 WP_228944310.1 hypothetical protein -
JH261_RS19460 (JH261_19460) 4525505..4526047 + 543 WP_076035808.1 GTPase -
JH261_RS19465 (JH261_19465) 4526382..4527065 + 684 WP_050911792.1 dTMP kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(23-42)

Antitoxin

(23-42)


Sequences


Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185456 WP_011270059.1 NZ_CP066926:c4522018-4521884 [Xanthomonas campestris pv. incanae]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185456 NZ_CP088229:c3819823-3819413 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTATTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185456 WP_011038999.1 NZ_CP066926:c4522247-4522095 [Xanthomonas campestris pv. incanae]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185456 NZ_CP088229:c3820070-3819804 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0


Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References