Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4643954..4644317 Replicon chromosome
Accession NZ_CP066923
Organism Xanthomonas campestris pv. incanae strain CFBP1606

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag JH295_RS20265 Protein ID WP_011270059.1
Coordinates 4643954..4644088 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag JH295_RS20270 Protein ID WP_011038999.1
Coordinates 4644165..4644317 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH295_RS20245 (JH295_20205) 4639221..4640873 - 1653 WP_070694617.1 M28 family metallopeptidase -
JH295_RS20250 (JH295_20210) 4641038..4641982 - 945 WP_070693782.1 MBL fold metallo-hydrolase -
JH295_RS20255 (JH295_20215) 4642066..4643355 - 1290 WP_057673596.1 tryptophan--tRNA ligase -
JH295_RS20260 (JH295_20220) 4643515..4643724 - 210 WP_011038998.1 CsbD family protein -
JH295_RS20265 (JH295_20225) 4643954..4644088 - 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
JH295_RS20270 (JH295_20230) 4644165..4644317 - 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
JH295_RS20275 (JH295_20235) 4644428..4645351 - 924 WP_070694619.1 arginase -
JH295_RS20280 (JH295_20240) 4645665..4646126 + 462 WP_042595651.1 roadblock/LC7 domain-containing protein -
JH295_RS20285 (JH295_20245) 4646209..4646568 + 360 WP_070693784.1 hypothetical protein -
JH295_RS20290 (JH295_20250) 4646671..4647588 + 918 WP_070693786.1 hypothetical protein -
JH295_RS20295 (JH295_20255) 4647585..4648127 + 543 WP_057673534.1 GTPase -
JH295_RS20300 (JH295_20260) 4648462..4649145 + 684 WP_070693788.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T185451 WP_011270059.1 NZ_CP066923:c4644088-4643954 [Xanthomonas campestris pv. incanae]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T185451 NZ_CP088229:462620-462970 [Enterobacter kobei]
ATGGTGAAGCGACCTTGTTTTGAACGAGGTGATATCGTTCTCGTCGGCTTCGATCCTGCAAATGGTCATGAACAAAAGGG
CGCAGGCAGGCCCGCTTTAGTGCTATCCGTTAGCGCGTTCAACCAGCTGGGAATGACGCTGGTTGCGCCTGTTACACAGG
GGGGAAATTTTGCCCGCTATGCGGGTTTCAGTGTGCCGCTGTCTTGTGAAGAAGGGAATATTCTGGGCGTCATTCTGGTA
AACCAAATCCGAATGATGGATTTGGGCGCGCGTCTGGCAAAACGAATAGGCGTGGCATCAGATGAAACCGTAGAAGATGC
GCTTTTAAGGCTACAGGCCATCCTGAGTTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT185451 WP_011038999.1 NZ_CP066923:c4644317-4644165 [Xanthomonas campestris pv. incanae]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT185451 NZ_CP088229:462375-462626 [Enterobacter kobei]
ATGCGTATAACCATTAAGAAATGGGGAAACAGTGCCGGTATGGTCATTCCTGGCGTAGTAATGAAAGAACTTGGCCTAAA
ACCAGGTCAGAGTATGGAGGCTCAGGTGACAAATAATCAGTTAGTGCTTACACCGGTGAGTAAACAGTACTCGCTTGAAG
AGTTGTTGGCGCAGTGTGATATGTCAGCCCCGGAAATTAACGAACAGGACGTATGGGGCACGTCAGGTCCCATAGGTGAC
GAAGTATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References