Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5231271..5232952 | Replicon | chromosome |
| Accession | NZ_CP066915 | ||
| Organism | Klebsiella pneumoniae strain XHKPN391 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | JG797_RS26110 | Protein ID | WP_002885155.1 |
| Coordinates | 5231271..5232188 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | JG797_RS26115 | Protein ID | WP_004151732.1 |
| Coordinates | 5232194..5232952 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JG797_RS26085 (5227051) | 5227051..5227512 | - | 462 | Protein_5121 | recombinase family protein | - |
| JG797_RS26090 (5227564) | 5227564..5228268 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| JG797_RS26095 (5228334) | 5228334..5229092 | + | 759 | Protein_5123 | ribose ABC transporter permease | - |
| JG797_RS26100 (5229123) | 5229123..5230064 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| JG797_RS26105 (5230139) | 5230139..5231146 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| JG797_RS26110 (5231271) | 5231271..5232188 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JG797_RS26115 (5232194) | 5232194..5232952 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JG797_RS26120 (5233038) | 5233038..5233766 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| JG797_RS26125 (5234039) | 5234039..5236186 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| JG797_RS26130 (5236416) | 5236416..5237102 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T185438 WP_002885155.1 NZ_CP066915:c5232188-5231271 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T185438 NZ_CP088221:c319899-319612 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT185438 WP_004151732.1 NZ_CP066915:c5232952-5232194 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT185438 NZ_CP088221:c320208-319906 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GH11 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GQB5 |