Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4668989..4669643 Replicon chromosome
Accession NZ_CP066915
Organism Klebsiella pneumoniae strain XHKPN391

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag JG797_RS23020 Protein ID WP_004144731.1
Coordinates 4668989..4669396 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JG797_RS23025 Protein ID WP_002916312.1
Coordinates 4669377..4669643 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG797_RS23000 (4664989) 4664989..4666722 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
JG797_RS23005 (4666728) 4666728..4667441 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JG797_RS23010 (4667464) 4667464..4668360 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JG797_RS23015 (4668461) 4668461..4668982 + 522 WP_002916308.1 flavodoxin FldB -
JG797_RS23020 (4668989) 4668989..4669396 - 408 WP_004144731.1 protein YgfX Toxin
JG797_RS23025 (4669377) 4669377..4669643 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JG797_RS23030 (4669889) 4669889..4670872 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JG797_RS23035 (4671023) 4671023..4671682 - 660 WP_002916317.1 hemolysin III family protein -
JG797_RS23040 (4671846) 4671846..4672157 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JG797_RS23045 (4672207) 4672207..4672935 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JG797_RS23050 (4673054) 4673054..4674487 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T185436 WP_004144731.1 NZ_CP066915:c4669396-4668989 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T185436 NZ_CP088218:1013007-1013186 [Staphylococcus sp. HL28]
ATGACTCAAAATAAAGATTCTAAAACAAATTACCATGAAGAAGAAAATGCAATGGTAACCGATTTAGATGATTTAAAAGA
CTTAGGAAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGAAAAATTAAATCAATCTCATGATTCAGATGTTCGTT
CTGATTTAGATCAAGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT185436 WP_002916312.1 NZ_CP066915:c4669643-4669377 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT185436 NZ_CP088218:1012380-1012979 [Staphylococcus sp. HL28]
ATGGCAATGAACTTTAAAGTATTTGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAATTTAA
TAACAACCCAATGACTATCGCAGGTGTTCATTTAACAAAAGATCATGCACCTGTATTAGATGAATTAAAAAAGAATGTTG
ATTTACATGCAGTTGATTTCAGTCAAATTAATATTTTAGATTATGATAAAAATCAATCATATTATGAAGCGTTAGGTGTA
CCACAAAGCCAAATTTATTCATTATCATATAACCAAGATGCTAATGACTTTATTTCAGATAAAATTAAAACGAAAGAAAA
TAAAGGTAAATTAGTATTACAAGTAGTTTCAATTGATGAAAATGGTCATTTAGATGTAAGTGTAAGACAAGGTTTACTAG
AAGCACGCGAAATCTTCTTAGTTGTTACTGGTAGTAATAAACGTGAAGTAGTCGAAAAATTATATAACGAAAATGGAAAA
TCTAACTTTGAACCTGCAGACTTAAAAGCGCACCGTATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGACGTGAAAGAATACTTCACAGCTCGCTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References