Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1330165..1330784 Replicon chromosome
Accession NZ_CP066915
Organism Klebsiella pneumoniae strain XHKPN391

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JG797_RS06440 Protein ID WP_002892050.1
Coordinates 1330165..1330383 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JG797_RS06445 Protein ID WP_002892066.1
Coordinates 1330410..1330784 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG797_RS06405 (1326212) 1326212..1326475 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
JG797_RS06410 (1326475) 1326475..1326615 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JG797_RS06415 (1326612) 1326612..1327310 - 699 WP_002892021.1 GNAT family protein -
JG797_RS06420 (1327411) 1327411..1328862 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JG797_RS06425 (1328837) 1328837..1329307 - 471 WP_002892026.1 YlaC family protein -
JG797_RS06430 (1329328) 1329328..1329468 + 141 WP_004147370.1 hypothetical protein -
JG797_RS06435 (1329440) 1329440..1330006 - 567 WP_002892030.1 maltose O-acetyltransferase -
JG797_RS06440 (1330165) 1330165..1330383 - 219 WP_002892050.1 HHA domain-containing protein Toxin
JG797_RS06445 (1330410) 1330410..1330784 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JG797_RS06450 (1331270) 1331270..1334416 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
JG797_RS06455 (1334439) 1334439..1335632 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185429 WP_002892050.1 NZ_CP066915:c1330383-1330165 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185429 NZ_CP088203:164021-164209 [Enterococcus durans]
ATGCCCATGACAATTAGAGAGGCAGAAAAATTACTCAAAGAAGCTGGCTTTGTCGAAGTGAAAGGTGGGAAGGGTTCTCA
CAGGAAATTTATCAAAGAGAATTTTCCGCGCCCGGTCATTCTTACCTGTCATTCAAAAGAGTTATCACAACGAGTAGAAA
ATACTGTCCGAAAGGCAGTGGGCTTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT185429 WP_002892066.1 NZ_CP066915:c1330784-1330410 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185429 NZ_CP088203:164245-164631 [Enterococcus durans]
ATGAAAAAAGTATATCCAGCTATTTTTGAAAAAGATCCCGTGGGGTATGGTATTTATTTTCCAGATGTGGAAGGTGCAGT
GACTCAAGCTGAAACTATTTTAGAAGGGCTGGAAGTCGCTTCGGATGCTCTTGGCATAATGCTTGGTGATTTGGTAGAGC
GTAATCTTCCTTTACCTGAGCCAAGTACTATGAAGGAAATTTCCTATGATCCTGAGACGGAGTTTGCTACATTAGTGTCA
GTGGAGTTAGATGACTACTTAAAAGATGTAAAACTTGATAAAAAGACGATAAAGATTCCACATTGGCTAAATGTTAGAGC
GACAAATGAAGGCATTAATTTTTCGAAAACGATGACTGAAGCGTTAGCTAAAAAACTGAATATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References