Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 217..691 | Replicon | plasmid pXHKPN083-4 |
| Accession | NZ_CP066914 | ||
| Organism | Klebsiella pneumoniae strain XHKPN083 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | A0A8J3DT22 |
| Locus tag | JG792_RS28805 | Protein ID | WP_004197762.1 |
| Coordinates | 217..483 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | S1EJF5 |
| Locus tag | JG792_RS28810 | Protein ID | WP_000879771.1 |
| Coordinates | 467..691 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JG792_RS28805 | 217..483 | - | 267 | WP_004197762.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JG792_RS28810 | 467..691 | - | 225 | WP_000879771.1 | DUF6290 family protein | Antitoxin |
| JG792_RS28815 | 854..982 | + | 129 | WP_000523570.1 | hypothetical protein | - |
| JG792_RS28820 | 1358..1570 | - | 213 | WP_021527181.1 | MbeD family mobilization/exclusion protein | - |
| JG792_RS28825 | 1577..2086 | - | 510 | WP_032433972.1 | MbeB family mobilization protein | - |
| JG792_RS28830 | 2121..2555 | - | 435 | Protein_6 | relaxase/mobilization nuclease domain-containing protein | - |
| JG792_RS28835 | 2764..3108 | - | 345 | WP_062955149.1 | MobC family plasmid mobilization relaxosome protein | - |
| JG792_RS28840 | 3098..3274 | - | 177 | WP_004197757.1 | hypothetical protein | - |
| JG792_RS28845 | 4430..4756 | + | 327 | WP_050516389.1 | hypothetical protein | - |
| JG792_RS28850 | 4782..5327 | + | 546 | WP_023317533.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..5596 | 5596 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10342.96 Da Isoelectric Point: 9.8727
>T185422 WP_004197762.1 NZ_CP066914:c483-217 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD
Download Length: 267 bp
>T185422 NZ_CP088200:2772375-2772518 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8369.28 Da Isoelectric Point: 4.6533
>AT185422 WP_000879771.1 NZ_CP066914:c691-467 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD
Download Length: 225 bp
>AT185422 NZ_CP088200:c2772635-2772451 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|