Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 234157..234679 Replicon plasmid pXHKPN083-1
Accession NZ_CP066911
Organism Klebsiella pneumoniae strain XHKPN083

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag JG792_RS27605 Protein ID WP_004181778.1
Coordinates 234157..234441 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag JG792_RS27610 Protein ID WP_004181777.1
Coordinates 234431..234679 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG792_RS27570 229795..230139 + 345 WP_228306996.1 hypothetical protein -
JG792_RS27575 230136..230507 + 372 WP_040209644.1 hypothetical protein -
JG792_RS27580 230552..231739 - 1188 WP_255054506.1 transposase -
JG792_RS27585 231775..232203 + 429 WP_077257669.1 IS200/IS605 family transposase -
JG792_RS27590 232282..232506 + 225 Protein_245 transposase -
JG792_RS27595 232777..234003 - 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
JG792_RS27600 234039..234140 + 102 Protein_247 IS200/IS605 family transposase -
JG792_RS27605 234157..234441 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG792_RS27610 234431..234679 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JG792_RS27615 234970..236769 + 1800 WP_004181776.1 ATP-dependent helicase -
JG792_RS27620 237103..238089 + 987 WP_101992392.1 hypothetical protein -
JG792_RS27625 238234..238587 + 354 WP_004181774.1 hypothetical protein -
JG792_RS27630 238649..239470 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / blaSHV-12 / aac(3)-IId / blaTEM-1B / mph(A) iucA / iucB / iucC / iucD / iutA / rmpA 1..302656 302656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T185412 WP_004181778.1 NZ_CP066911:c234441-234157 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T185412 NZ_CP088198:c2543904-2543752 [Enterococcus faecalis]
GTGGTGCGTATGAGCGCACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAAAAAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT185412 WP_004181777.1 NZ_CP066911:c234679-234431 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT185412 NZ_CP088198:2543633-2543819 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References