Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 143871..144781 Replicon plasmid pXHKPN083-1
Accession NZ_CP066911
Organism Klebsiella pneumoniae strain XHKPN083

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag JG792_RS27180 Protein ID WP_004026354.1
Coordinates 143871..144341 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag JG792_RS27185 Protein ID WP_004181895.1
Coordinates 144338..144781 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG792_RS27155 138886..139554 + 669 WP_001300294.1 EAL domain-containing protein -
JG792_RS27160 139629..140879 + 1251 Protein_159 transposase -
JG792_RS27165 140944..141648 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
JG792_RS27170 141749..142930 + 1182 WP_078207741.1 IS481 family transposase -
JG792_RS27175 143501..143761 + 261 WP_004026352.1 hypothetical protein -
JG792_RS27180 143871..144341 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
JG792_RS27185 144338..144781 - 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
JG792_RS27190 144882..146153 - 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
JG792_RS27195 146153..146575 - 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
JG792_RS27200 146661..148148 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
JG792_RS27205 148976..149455 - 480 WP_004181843.1 hypothetical protein -
JG792_RS27210 149539..149745 - 207 WP_004026437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / blaSHV-12 / aac(3)-IId / blaTEM-1B / mph(A) iucA / iucB / iucC / iucD / iutA / rmpA 1..302656 302656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T185411 WP_004026354.1 NZ_CP066911:c144341-143871 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T185411 NZ_CP088198:c2543481-2543377 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT185411 WP_004181895.1 NZ_CP066911:c144781-144338 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT185411 NZ_CP088198:2543257-2543444 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References