Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 143871..144781 | Replicon | plasmid pXHKPN083-1 |
Accession | NZ_CP066911 | ||
Organism | Klebsiella pneumoniae strain XHKPN083 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | JG792_RS27180 | Protein ID | WP_004026354.1 |
Coordinates | 143871..144341 (-) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A2J4RLY9 |
Locus tag | JG792_RS27185 | Protein ID | WP_004181895.1 |
Coordinates | 144338..144781 (-) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JG792_RS27155 | 138886..139554 | + | 669 | WP_001300294.1 | EAL domain-containing protein | - |
JG792_RS27160 | 139629..140879 | + | 1251 | Protein_159 | transposase | - |
JG792_RS27165 | 140944..141648 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
JG792_RS27170 | 141749..142930 | + | 1182 | WP_078207741.1 | IS481 family transposase | - |
JG792_RS27175 | 143501..143761 | + | 261 | WP_004026352.1 | hypothetical protein | - |
JG792_RS27180 | 143871..144341 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
JG792_RS27185 | 144338..144781 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
JG792_RS27190 | 144882..146153 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
JG792_RS27195 | 146153..146575 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
JG792_RS27200 | 146661..148148 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
JG792_RS27205 | 148976..149455 | - | 480 | WP_004181843.1 | hypothetical protein | - |
JG792_RS27210 | 149539..149745 | - | 207 | WP_004026437.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / blaSHV-12 / aac(3)-IId / blaTEM-1B / mph(A) | iucA / iucB / iucC / iucD / iutA / rmpA | 1..302656 | 302656 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T185411 WP_004026354.1 NZ_CP066911:c144341-143871 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T185411 NZ_CP088198:c2543481-2543377 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATT
GCTTAAAAATGACAATAAAAAATAA
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATT
GCTTAAAAATGACAATAAAAAATAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT185411 WP_004181895.1 NZ_CP066911:c144781-144338 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT185411 NZ_CP088198:2543257-2543444 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4RLY9 |