Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2712257..2713845 Replicon chromosome
Accession NZ_CP066910
Organism Klebsiella pneumoniae strain XHKPN083

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag JG792_RS13460 Protein ID WP_004199851.1
Coordinates 2712257..2713579 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JG792_RS13465 Protein ID WP_002904790.1
Coordinates 2713579..2713845 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG792_RS13445 2707322..2709823 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
JG792_RS13450 2709811..2710815 + 1005 WP_004199852.1 fimbrial protein -
JG792_RS13455 2710948..2712240 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JG792_RS13460 2712257..2713579 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
JG792_RS13465 2713579..2713845 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JG792_RS13470 2714111..2714437 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JG792_RS13475 2714434..2714934 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JG792_RS13480 2714912..2716291 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
JG792_RS13485 2716637..2717791 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JG792_RS13490 2717772..2718695 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T185404 WP_004199851.1 NZ_CP066910:c2713579-2712257 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T185404 NZ_CP088158:c2448186-2448079 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT185404 WP_002904790.1 NZ_CP066910:c2713845-2713579 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT185404 NZ_CP088158:2448002-2448062 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References