Detailed information of TA system TA185384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 55225..56135
• Replicon: plasmid pXHKP502-1
• Accession: NZ_CP066905
• Organism: Klebsiella pneumoniae strain XHKP502

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A663AYG0
• Locus tag: JG791_RS27440
• Protein ID: WP_004026354.1
• Coordinates: 55225..55695 (-)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6P1V3Q9
• Locus tag: JG791_RS27445
• Protein ID: WP_004026357.1
• Coordinates: 55692..56135 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG791_RS27415	50637..51035	-	399	WP_004212796.1	H-NS family nucleoid-associated regulatory protein	-
JG791_RS27420	51372..51866	-	495	WP_004212794.1	thermonuclease family protein	-
JG791_RS27425	52044..52310	+	267	WP_223175074.1	DUF1173 family protein	-
JG791_RS27430	52343..52993	+	651	WP_068893702.1	DUF1173 family protein	-
JG791_RS27440	55225..55695	-	471	WP_004026354.1	RES family NAD+ phosphorylase	Toxin
JG791_RS27445	55692..56135	-	444	WP_004026357.1	DUF2384 domain-containing protein	Antitoxin
JG791_RS27450	56236..56739	-	504	Protein_65	DUF4113 domain-containing protein	-
JG791_RS27455	56945..57925	-	981	WP_000019473.1	IS5-like element ISKpn26 family transposase	-
JG791_RS27460	57991..59298	+	1308	Protein_67	FepA family TonB-dependent siderophore receptor	-
JG791_RS27465	59360..59581	+	222	WP_004213615.1	hypothetical protein	-
JG791_RS27470	59724..60626	-	903	WP_004213613.1	DMT family inner membrane transporter PEG344	-
JG791_RS27475	60699..61100	-	402	WP_214588034.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2	1..221472	221472
	-	inside	IScluster/Tn	-	iroN / rmpA	49186..70121	20935

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17515.79 Da
• Isoelectric Point: 4.6155

>T185384 WP_004026354.1 NZ_CP066905:c55695-55225 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T185384 NZ_CP088156:c7975895-7975566 [Bradyrhizobium sp. A19]
ATGGCAACGACGCGCTTCGATGCCGCGGAATATCTTGCAGAGCCGGAGGCCCAAGCCGAGTTTCTGGCGGCGGCGCTTGA
GGACGGCACCGCTGATGAAATCCGCGCCGCGATCAACACAATTGCCCGAGCGCGCGGCATGACGGAAGTCGCCAAGGCAA
CCGGCATCCGTCGCGAACAGCTTTATCGGGCACTTGGTGAAGACGGGAATCCGGAGTTCGCCACCATCCTCAAGGTGATC
CGCGCTCTCGGCGTGAAGCTCACCTCAGCGCCGCCCAAGGCTGCTCCGAAGCGGAAGTCTGCCAAGAAAGCAGGCCGCCG
GGCCGCGTAG

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16480.80 Da
• Isoelectric Point: 10.2498

>AT185384 WP_004026357.1 NZ_CP066905:c56135-55692 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT185384 NZ_CP088156:c7976192-7975899 [Bradyrhizobium sp. A19]
ATGCTCGAGGTCCGGCAGACCAGCGAGTTCAAGGAATGGCTTCTTGGTCTGCGAGATGCGAGAGCAAAGGCACGTATTGC
GGCTCGCATTGCCCGTGCTGAAGGTGGCAACCTCGGTGACAGCAAGCCGGTTGGTGGGGGCGTCTCCCAAATGCTGATCG
ATTACGGCCCCGGCTATCGGGTCTATTTGCGCCAGAAAGGCAACGTCCTGGTGATCCTGCTTTGCGGTGGTGACAAGAGC
ATCCAGCGCTCCGATATCCGGCGCGCTCAAGAATTGGCCGAGAGAGAGGGGTAG

Structures

Toxin

• AlphaFold DB: A0A663AYG0

Antitoxin

• AlphaFold DB: A0A6P1V3Q9