Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5399976..5400601 Replicon chromosome
Accession NZ_CP066904
Organism Klebsiella pneumoniae strain XHKP502

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JG791_RS26760 Protein ID WP_002882817.1
Coordinates 5399976..5400359 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JG791_RS26765 Protein ID WP_004150355.1
Coordinates 5400359..5400601 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG791_RS26745 5397342..5398244 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JG791_RS26750 5398241..5398876 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JG791_RS26755 5398873..5399802 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JG791_RS26760 5399976..5400359 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JG791_RS26765 5400359..5400601 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
JG791_RS26770 5400806..5401723 + 918 WP_002882812.1 alpha/beta hydrolase -
JG791_RS26775 5401737..5402678 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JG791_RS26780 5402723..5403160 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
JG791_RS26785 5403157..5404017 - 861 WP_002882807.1 virulence factor BrkB family protein -
JG791_RS26790 5404011..5404610 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T185382 WP_002882817.1 NZ_CP066904:c5400359-5399976 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T185382 NZ_CP088156:c6302153-6301869 [Bradyrhizobium sp. A19]
ATGATTGTCGGCTACCGGGACAGAAGGACCGAGCGCTTTGCGAATGGCGAAGTTGTTCGGGAATTCTCCGGGTTCGCCCG
GCAGGCGGAGATACGGCTCGATCGGCTGGAAGCCGCAACAAGCTTGAAGGATCTTGCCGCCTTGCCGGGCAACCGGTTGG
AGAGGCTCAAAGGCAATCGGCAGGGCCAGTACAGCATCCGCATCAATGATCAATGGCGGATCTGTTTTGAATGGCCCGCC
GGCTCACCCGGCCCAGTCAATGTCGAGATCGTCGACTATCACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT185382 WP_004150355.1 NZ_CP066904:c5400601-5400359 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT185382 NZ_CP088156:c6301858-6301556 [Bradyrhizobium sp. A19]
ATGGCACGCAGCCCCATTCATCCGGGCGTTCATCTCGCCGAAGAGCTCGACGAACTCGGCCTATCGGCCGCAGAGCTGTC
GCGCCAGCTCGACGTGCCTGTCAACCGGATCACCGCAATTATCAACGGCCAGCGCGGCATCACCGCCGATACTGCGTTAC
GCCTGGGCCACTGGTTCGGGACCAGCCCGGATTTCTGGCTCAACCTGCAAAAGATCTACGAATTGCGATTGGCGCAGCAG
GAGGTCGGCGACCTCGTCAAAAGGCTGCCGACCCGTGCAGGACTTCGGACGCAGGCTGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References