Detailed information of TA system TA185381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5075925..5077606
• Replicon: chromosome
• Accession: NZ_CP066904
• Organism: Klebsiella pneumoniae strain XHKP502

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: JG791_RS25255
• Protein ID: WP_002885155.1
• Coordinates: 5075925..5076842 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: JG791_RS25260
• Protein ID: WP_004151732.1
• Coordinates: 5076848..5077606 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG791_RS25235	5071231..5072751	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
JG791_RS25240	5072748..5073746	+	999	WP_002885172.1	ribose ABC transporter permease	-
JG791_RS25245	5073777..5074718	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JG791_RS25250	5074793..5075800	+	1008	WP_004151731.1	carbohydrate kinase family protein	-
JG791_RS25255	5075925..5076842	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JG791_RS25260	5076848..5077606	-	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JG791_RS25265	5077692..5078420	-	729	WP_002885152.1	response regulator transcription factor	-
JG791_RS25270	5078693..5080840	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
JG791_RS25275	5081070..5081756	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T185381 WP_002885155.1 NZ_CP066904:c5076842-5075925 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T185381 NZ_CP088156:2224310-2224591 [Bradyrhizobium sp. A19]
ATGATCCGCAGCTTCGCTGACAGGGCCACCGAGCGGCTGTTCCGCGACCATGTCTGTCCCGCAAAGTGGCGGAACTTCGA
AGCCATCGCTTTGCGGAAGCTCGACATGGTAGATGCTGCCGTCCGTCTGGACGATCTGCGGTCCCCGCCGGGTAATCGAC
TGGAGGCGCTAAAAGGCGATCGCCGGGGTCAACATTCCATCAGGATCAACCAGCAATGGCGGATCTGCTTTGAATGGACG
CCAGAGGGTCCGGCACTGGTGGAGATCATAGATTATCACTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT185381 WP_004151732.1 NZ_CP066904:c5077606-5076848 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT185381 NZ_CP088156:2224603-2224887 [Bradyrhizobium sp. A19]
ATGCCCCGCCTGCGCACCCATCCCGGCGAAGTGCTCCGCGAGGAATTCCTCCTTCCTCTCGGGCTGTCCGCGCGTTCGCT
GGCGAAAATGCTGGACGTTCCGCCCAATCGCCTCACCGAGATCATGCGCGGCACTCGCGATGTCACGGCCGACACCGCGC
TCCGGCTCGGCCGCTACTTCGGCACCGACCCGCGCTTCTGGATGAACTTGCAGACCGCCTACGACCTCTCGAAGGCGGAG
CAGACCCAGAACTACAAGAAGATCGTGCCGCGCGACGCCGCTTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5