Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4919741..4920257 Replicon chromosome
Accession NZ_CP066904
Organism Klebsiella pneumoniae strain XHKP502

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JG791_RS24455 Protein ID WP_002886902.1
Coordinates 4919741..4920025 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JG791_RS24460 Protein ID WP_002886901.1
Coordinates 4920015..4920257 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG791_RS24430 4915225..4915488 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
JG791_RS24435 4915618..4915791 + 174 WP_002886906.1 hypothetical protein -
JG791_RS24440 4915794..4916537 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JG791_RS24445 4916894..4919032 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JG791_RS24450 4919273..4919737 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JG791_RS24455 4919741..4920025 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG791_RS24460 4920015..4920257 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JG791_RS24465 4920335..4922245 - 1911 WP_004152270.1 PRD domain-containing protein -
JG791_RS24470 4922268..4923422 - 1155 WP_002886900.1 lactonase family protein -
JG791_RS24475 4923488..4924228 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T185380 WP_002886902.1 NZ_CP066904:c4920025-4919741 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T185380 NZ_CP066904:c4920025-4919741 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT185380 WP_002886901.1 NZ_CP066904:c4920257-4920015 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT185380 NZ_CP066904:c4920257-4920015 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References