185378

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4203756..4204375 Replicon chromosome
Accession NZ_CP066904
Organism Klebsiella pneumoniae strain XHKP502

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JG791_RS21015 Protein ID WP_002892050.1
Coordinates 4204157..4204375 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JG791_RS21010 Protein ID WP_002892066.1
Coordinates 4203756..4204130 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG791_RS21000 4198908..4200101 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JG791_RS21005 4200124..4203270 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
JG791_RS21010 4203756..4204130 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JG791_RS21015 4204157..4204375 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JG791_RS21020 4204534..4205100 + 567 WP_002892030.1 maltose O-acetyltransferase -
JG791_RS21025 4205072..4205212 - 141 WP_004147370.1 hypothetical protein -
JG791_RS21030 4205233..4205703 + 471 WP_002892026.1 YlaC family protein -
JG791_RS21035 4205678..4207129 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JG791_RS21040 4207230..4207928 + 699 WP_002892021.1 GNAT family protein -
JG791_RS21045 4207925..4208065 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JG791_RS21050 4208065..4208328 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185378 WP_002892050.1 NZ_CP066904:4204157-4204375 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185378 NZ_CP088156:1629377-1629673 [Bradyrhizobium sp. A19]
ATGATTGTCAGCTTCCGTGATGATTGGCTGCGTCATTTCTTCGTCGACGACGTCAGATCGAAAAAGATTCCAGCCGACCT
TGAGGACCGCCTGTTCCGCAGGCTCCAGATGATCGACGACGCGACGATGGATCGAGACCTAAGATCGCCGCCCAGCAATC
ATTTCGAGAAGCTGCGTGGCCATCTCGACGGCTTTCATTCGATCCGCGTCAACAAGCGCTGGCGGTTGGTGTTCCGTTGG
CACAGTGGCCGCGGGGAAGCGAGTGAACTCTATCTTGACGACCACAGCTACGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT185378 WP_002892066.1 NZ_CP066904:4203756-4204130 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185378 NZ_CP088156:1629682-1629990 [Bradyrhizobium sp. A19]
ATGCTGATGACCAAACGCAAGCCAGTGACAGTGGCTGAAATCCTGGTCGAAGAATTCATGGCGCCGATGGGCCTGACGCA
AACCGCGTTGGCCGCGGCGATGGGGGTACAGCGCAAGCACGTCAACGAGCTCTGCAACGGCCGCCGCAACGTCACGGCGG
CAACTGCGCTGATCCTCGCGCGCGTTTTTGGCAATGGTCCCGAGTTCTGGCTCAACGTGCAGCGGCGCAGCGACCTCTGG
GAAGCGATGCATTCGCCCCGCGAGCGTAAGCGGATCGAGCGAGCCAAGCCGCTGAATTCCGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References