Detailed information of TA system TA185377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2739758..2741346
• Replicon: chromosome
• Accession: NZ_CP066904
• Organism: Klebsiella pneumoniae strain XHKP502

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0H3GN97
• Locus tag: JG791_RS13620
• Protein ID: WP_004199851.1
• Coordinates: 2739758..2741080 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: JG791_RS13625
• Protein ID: WP_002904790.1
• Coordinates: 2741080..2741346 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG791_RS13605	2734823..2737324	+	2502	WP_004199853.1	fimbria/pilus outer membrane usher protein	-
JG791_RS13610	2737312..2738316	+	1005	WP_004199852.1	fimbrial protein	-
JG791_RS13615	2738449..2739741	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
JG791_RS13620	2739758..2741080	-	1323	WP_004199851.1	type II toxin-antitoxin system HipA family toxin	Toxin
JG791_RS13625	2741080..2741346	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JG791_RS13630	2741612..2741938	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
JG791_RS13635	2741935..2742435	-	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JG791_RS13640	2742413..2743792	-	1380	WP_004199850.1	nucleobase:cation symporter-2 family protein	-
JG791_RS13645	2744138..2745292	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
JG791_RS13650	2745273..2746196	-	924	WP_004199849.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49128.44 Da
• Isoelectric Point: 7.2487

>T185377 WP_004199851.1 NZ_CP066904:c2741080-2739758 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T185377 NZ_CP088151:c6591539-6591147 [Mesorhizobium mediterraneum]
ATGTTCGTCGACACCTCCGTGGTTGTCGCGATTCTTTCAGGAGAAGAGGATGCCGGCGAGTGGAGCAACCGCATCGAGGC
AGCGCCAGCAAGGATAACTTCGGCGCTGGTCGTGCTTGAAGCGGCGATGCGGCTTTCAACGATGCTCGCCGTCCAGCCGG
TTGTCGCCGGGGACGCGATAGAGGCGTTTCTTCGCGAGGCTGAAATCGAAATCGTGCCGATCGACGCCGGCGATGCCGCG
CTCGCGATCCAGGCGTTTTCAGACTATGGAAAGGGGCGTGGGCATCCCGCCCAGCTCAACTTAGCCGACTGCCTTTCTTA
TGCCTGCGCAAAAAGTCATGGCTCCGCACTGCTCTACAAGGGTAACGATTTTTCGCATACCGATCTCGCGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT185377 WP_002904790.1 NZ_CP066904:c2741346-2741080 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT185377 NZ_CP088151:c6591781-6591539 [Mesorhizobium mediterraneum]
ATGAATCTTCAGATCAGGGACCCGCGCGCACGCGAACTGGCGCGAGAGCTTGCTGCCAAACGAAAGATTTCGATGACCGA
AGCGGTCATCGAAGCGCTTGAATCCGAATTGAAGCGGGAAAGCGGACGCATTCCCCTGGCGGAGCGGCTCGCTGCCATTG
CCAACGACTTCAAGGCCAAGGCAGGCCAGGGCGGTCGGGCTGTCAACAAGGATGAGATCGACGAAATGTGGGGACATTCC
TAA

Structures

Toxin

• AlphaFold DB: A0A0H3GN97

Antitoxin

• AlphaFold DB: A0A0H3GXD8