Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2739758..2741346 Replicon chromosome
Accession NZ_CP066904
Organism Klebsiella pneumoniae strain XHKP502

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag JG791_RS13620 Protein ID WP_004199851.1
Coordinates 2739758..2741080 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JG791_RS13625 Protein ID WP_002904790.1
Coordinates 2741080..2741346 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG791_RS13605 2734823..2737324 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
JG791_RS13610 2737312..2738316 + 1005 WP_004199852.1 fimbrial protein -
JG791_RS13615 2738449..2739741 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JG791_RS13620 2739758..2741080 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
JG791_RS13625 2741080..2741346 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JG791_RS13630 2741612..2741938 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JG791_RS13635 2741935..2742435 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JG791_RS13640 2742413..2743792 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
JG791_RS13645 2744138..2745292 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JG791_RS13650 2745273..2746196 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T185377 WP_004199851.1 NZ_CP066904:c2741080-2739758 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T185377 NZ_CP088151:c6591539-6591147 [Mesorhizobium mediterraneum]
ATGTTCGTCGACACCTCCGTGGTTGTCGCGATTCTTTCAGGAGAAGAGGATGCCGGCGAGTGGAGCAACCGCATCGAGGC
AGCGCCAGCAAGGATAACTTCGGCGCTGGTCGTGCTTGAAGCGGCGATGCGGCTTTCAACGATGCTCGCCGTCCAGCCGG
TTGTCGCCGGGGACGCGATAGAGGCGTTTCTTCGCGAGGCTGAAATCGAAATCGTGCCGATCGACGCCGGCGATGCCGCG
CTCGCGATCCAGGCGTTTTCAGACTATGGAAAGGGGCGTGGGCATCCCGCCCAGCTCAACTTAGCCGACTGCCTTTCTTA
TGCCTGCGCAAAAAGTCATGGCTCCGCACTGCTCTACAAGGGTAACGATTTTTCGCATACCGATCTCGCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT185377 WP_002904790.1 NZ_CP066904:c2741346-2741080 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT185377 NZ_CP088151:c6591781-6591539 [Mesorhizobium mediterraneum]
ATGAATCTTCAGATCAGGGACCCGCGCGCACGCGAACTGGCGCGAGAGCTTGCTGCCAAACGAAAGATTTCGATGACCGA
AGCGGTCATCGAAGCGCTTGAATCCGAATTGAAGCGGGAAAGCGGACGCATTCCCCTGGCGGAGCGGCTCGCTGCCATTG
CCAACGACTTCAAGGCCAAGGCAGGCCAGGGCGGTCGGGCTGTCAACAAGGATGAGATCGACGAAATGTGGGGACATTCC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References