185357

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 15895..16538 Replicon plasmid pXHKP309-1
Accession NZ_CP066901
Organism Klebsiella pneumoniae strain XHKP309

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag JG788_RS26875 Protein ID WP_001044770.1
Coordinates 15895..16311 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag JG788_RS26880 Protein ID WP_001261282.1
Coordinates 16308..16538 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG788_RS26855 (11998) 11998..12270 - 273 Protein_15 transposase -
JG788_RS26865 (13252) 13252..14274 - 1023 WP_000361404.1 helicase UvrD -
JG788_RS26870 (14259) 14259..15821 - 1563 WP_004206609.1 AAA family ATPase -
JG788_RS26875 (15895) 15895..16311 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
JG788_RS26880 (16308) 16308..16538 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JG788_RS26885 (16495) 16495..16956 + 462 WP_014343465.1 hypothetical protein -
JG788_RS26890 (17117) 17117..18061 + 945 WP_011977810.1 hypothetical protein -
JG788_RS26895 (18098) 18098..18490 + 393 WP_011977811.1 hypothetical protein -
JG788_RS26900 (18548) 18548..19069 + 522 WP_013214008.1 hypothetical protein -
JG788_RS26905 (19115) 19115..19318 + 204 WP_011977813.1 hypothetical protein -
JG788_RS26910 (19348) 19348..20352 + 1005 WP_011977814.1 hypothetical protein -
JG788_RS26915 (20536) 20536..21315 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 / catA2 / mph(A) / blaTEM-1B / rmtB / fosA3 / blaCTX-M-55 - 1..178237 178237


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T185357 WP_001044770.1 NZ_CP066901:c16311-15895 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T185357 NZ_CP088143:23699-24097 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCTGAAGTTTATGCTGGATACCAATATCTGTATCTTTACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCGGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACGCGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT185357 WP_001261282.1 NZ_CP066901:c16538-16308 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT185357 NZ_CP088143:23472-23699 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGGAAACCAGCGTATTTCTCAGTAACCGAAGCCAGGCGGTCAGACTGCCAAAAGCAGTGGCATTGCCGGAACATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGGATCATCACGCCAGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References