185356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5361410..5362035 Replicon chromosome
Accession NZ_CP066900
Organism Klebsiella pneumoniae strain XHKP309

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JG788_RS26415 Protein ID WP_002882817.1
Coordinates 5361410..5361793 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JG788_RS26420 Protein ID WP_004150355.1
Coordinates 5361793..5362035 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG788_RS26400 5358776..5359678 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JG788_RS26405 5359675..5360310 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JG788_RS26410 5360307..5361236 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JG788_RS26415 5361410..5361793 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JG788_RS26420 5361793..5362035 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
JG788_RS26425 5362240..5363157 + 918 WP_002882812.1 alpha/beta hydrolase -
JG788_RS26430 5363171..5364112 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JG788_RS26435 5364157..5364594 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
JG788_RS26440 5364591..5365451 - 861 WP_002882807.1 virulence factor BrkB family protein -
JG788_RS26445 5365445..5366044 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T185356 WP_002882817.1 NZ_CP066900:c5361793-5361410 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T185356 NZ_CP088142:4474699-4475010 [Salmonella enterica subsp. enterica serovar Gallinarum]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT185356 WP_004150355.1 NZ_CP066900:c5362035-5361793 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT185356 NZ_CP088142:4475007-4475453 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References