Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4164094..4164713 Replicon chromosome
Accession NZ_CP066900
Organism Klebsiella pneumoniae strain XHKP309

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JG788_RS20660 Protein ID WP_002892050.1
Coordinates 4164495..4164713 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JG788_RS20655 Protein ID WP_002892066.1
Coordinates 4164094..4164468 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG788_RS20645 4159246..4160439 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JG788_RS20650 4160462..4163608 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
JG788_RS20655 4164094..4164468 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JG788_RS20660 4164495..4164713 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JG788_RS20665 4164872..4165438 + 567 WP_002892030.1 maltose O-acetyltransferase -
JG788_RS20670 4165410..4165550 - 141 WP_004147370.1 hypothetical protein -
JG788_RS20675 4165571..4166041 + 471 WP_002892026.1 YlaC family protein -
JG788_RS20680 4166016..4167467 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JG788_RS20685 4167568..4168266 + 699 WP_002892021.1 GNAT family protein -
JG788_RS20690 4168263..4168403 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JG788_RS20695 4168403..4168666 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185352 WP_002892050.1 NZ_CP066900:4164495-4164713 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185352 NZ_CP088142:c4016251-4015943 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT185352 WP_002892066.1 NZ_CP066900:4164094-4164468 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185352 NZ_CP088142:c4016493-4016254 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References