Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5405885..5406510 Replicon chromosome
Accession NZ_CP066895
Organism Klebsiella pneumoniae strain XHKP75

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JG785_RS26690 Protein ID WP_002882817.1
Coordinates 5405885..5406268 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JG785_RS26695 Protein ID WP_004150355.1
Coordinates 5406268..5406510 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG785_RS26675 5403251..5404153 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JG785_RS26680 5404150..5404785 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JG785_RS26685 5404782..5405711 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JG785_RS26690 5405885..5406268 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JG785_RS26695 5406268..5406510 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
JG785_RS26700 5406715..5407632 + 918 WP_002882812.1 alpha/beta hydrolase -
JG785_RS26705 5407646..5408587 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JG785_RS26710 5408632..5409069 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
JG785_RS26715 5409066..5409926 - 861 WP_002882807.1 virulence factor BrkB family protein -
JG785_RS26720 5409920..5410519 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T185329 WP_002882817.1 NZ_CP066895:c5406268-5405885 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T185329 NZ_CP088138:881271-881669 [Salmonella enterica subsp. enterica serovar Hissar]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT185329 WP_004150355.1 NZ_CP066895:c5406510-5406268 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT185329 NZ_CP088138:881044-881271 [Salmonella enterica subsp. enterica serovar Hissar]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References