Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4924584..4925100 Replicon chromosome
Accession NZ_CP066895
Organism Klebsiella pneumoniae strain XHKP75

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JG785_RS24375 Protein ID WP_002886902.1
Coordinates 4924584..4924868 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JG785_RS24380 Protein ID WP_002886901.1
Coordinates 4924858..4925100 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG785_RS24350 4920068..4920331 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
JG785_RS24355 4920461..4920634 + 174 WP_002886906.1 hypothetical protein -
JG785_RS24360 4920637..4921380 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JG785_RS24365 4921737..4923875 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JG785_RS24370 4924116..4924580 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JG785_RS24375 4924584..4924868 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG785_RS24380 4924858..4925100 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JG785_RS24385 4925178..4927088 - 1911 WP_004152270.1 PRD domain-containing protein -
JG785_RS24390 4927111..4928265 - 1155 WP_002886900.1 lactonase family protein -
JG785_RS24395 4928331..4929071 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T185327 WP_002886902.1 NZ_CP066895:c4924868-4924584 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T185327 NZ_CP088138:364861-365136 [Salmonella enterica subsp. enterica serovar Hissar]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT185327 WP_002886901.1 NZ_CP066895:c4925100-4924858 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT185327 NZ_CP088138:364598-364858 [Salmonella enterica subsp. enterica serovar Hissar]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References