Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4208591..4209210 Replicon chromosome
Accession NZ_CP066895
Organism Klebsiella pneumoniae strain XHKP75

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JG785_RS20935 Protein ID WP_002892050.1
Coordinates 4208992..4209210 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JG785_RS20930 Protein ID WP_002892066.1
Coordinates 4208591..4208965 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG785_RS20920 4203743..4204936 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JG785_RS20925 4204959..4208105 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
JG785_RS20930 4208591..4208965 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JG785_RS20935 4208992..4209210 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JG785_RS20940 4209369..4209935 + 567 WP_002892030.1 maltose O-acetyltransferase -
JG785_RS20945 4209907..4210047 - 141 WP_004147370.1 hypothetical protein -
JG785_RS20950 4210068..4210538 + 471 WP_002892026.1 YlaC family protein -
JG785_RS20955 4210513..4211964 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JG785_RS20960 4212065..4212763 + 699 WP_002892021.1 GNAT family protein -
JG785_RS20965 4212760..4212900 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JG785_RS20970 4212900..4213163 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185325 WP_002892050.1 NZ_CP066895:4208992-4209210 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185325 NZ_CP088138:206804-207289 [Salmonella enterica subsp. enterica serovar Hissar]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT185325 WP_002892066.1 NZ_CP066895:4208591-4208965 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185325 NZ_CP088138:206529-206816 [Salmonella enterica subsp. enterica serovar Hissar]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References