Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11795..12438 Replicon plasmid pXHKP53-1
Accession NZ_CP066892
Organism Klebsiella pneumoniae strain XHKP53

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag JG783_RS26730 Protein ID WP_001044770.1
Coordinates 12022..12438 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag JG783_RS26725 Protein ID WP_001261282.1
Coordinates 11795..12025 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG783_RS26690 (7019) 7019..7798 - 780 WP_013214009.1 site-specific integrase -
JG783_RS26695 (7982) 7982..8986 - 1005 WP_011977814.1 hypothetical protein -
JG783_RS26700 (9016) 9016..9219 - 204 WP_011977813.1 hypothetical protein -
JG783_RS26705 (9265) 9265..9786 - 522 WP_013214008.1 hypothetical protein -
JG783_RS26710 (9844) 9844..10236 - 393 WP_011977811.1 hypothetical protein -
JG783_RS26715 (10273) 10273..11216 - 944 Protein_12 hypothetical protein -
JG783_RS26720 (11377) 11377..11838 - 462 WP_014343465.1 hypothetical protein -
JG783_RS26725 (11795) 11795..12025 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JG783_RS26730 (12022) 12022..12438 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
JG783_RS26735 (12512) 12512..14074 + 1563 WP_004206609.1 AAA family ATPase -
JG783_RS26740 (14059) 14059..15081 + 1023 WP_000361404.1 helicase UvrD -
JG783_RS26745 (15337) 15337..16034 + 698 WP_223174630.1 IS1 family transposase -
JG783_RS26750 (16063) 16063..16335 + 273 Protein_19 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaKPC-2 / blaSHV-12 / rmtB / blaTEM-1B / fosA3 / blaCTX-M-65 / catA2 - 1..147717 147717


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T185303 WP_001044770.1 NZ_CP066892:12022-12438 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T185303 NZ_CP088134:c2957135-2956737 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT185303 WP_001261282.1 NZ_CP066892:11795-12025 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT185303 NZ_CP088134:c2957362-2957135 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References