Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5331406..5332031 Replicon chromosome
Accession NZ_CP066891
Organism Klebsiella pneumoniae strain XHKP53

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JG783_RS26290 Protein ID WP_002882817.1
Coordinates 5331406..5331789 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JG783_RS26295 Protein ID WP_004150355.1
Coordinates 5331789..5332031 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG783_RS26275 5328772..5329674 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JG783_RS26280 5329671..5330306 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JG783_RS26285 5330303..5331232 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JG783_RS26290 5331406..5331789 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JG783_RS26295 5331789..5332031 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
JG783_RS26300 5332236..5333153 + 918 WP_002882812.1 alpha/beta hydrolase -
JG783_RS26305 5333167..5334108 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JG783_RS26310 5334153..5334590 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
JG783_RS26315 5334587..5335447 - 861 WP_002882807.1 virulence factor BrkB family protein -
JG783_RS26320 5335441..5336040 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T185302 WP_002882817.1 NZ_CP066891:c5331789-5331406 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T185302 NZ_CP088134:2461012-2461380 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
TATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT185302 WP_004150355.1 NZ_CP066891:c5332031-5331789 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT185302 NZ_CP088134:2460794-2461015 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References