Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4851223..4851739 Replicon chromosome
Accession NZ_CP066891
Organism Klebsiella pneumoniae strain XHKP53

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JG783_RS23985 Protein ID WP_002886902.1
Coordinates 4851223..4851507 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JG783_RS23990 Protein ID WP_002886901.1
Coordinates 4851497..4851739 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG783_RS23960 4846707..4846970 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
JG783_RS23965 4847100..4847273 + 174 WP_002886906.1 hypothetical protein -
JG783_RS23970 4847276..4848019 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JG783_RS23975 4848376..4850514 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JG783_RS23980 4850755..4851219 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JG783_RS23985 4851223..4851507 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG783_RS23990 4851497..4851739 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JG783_RS23995 4851817..4853727 - 1911 WP_004152270.1 PRD domain-containing protein -
JG783_RS24000 4853750..4854904 - 1155 WP_002886900.1 lactonase family protein -
JG783_RS24005 4854970..4855710 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T185300 WP_002886902.1 NZ_CP066891:c4851507-4851223 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T185300 NZ_CP088134:2344593-2345078 [Salmonella enterica subsp. enterica serovar Gallinarum]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT185300 WP_002886901.1 NZ_CP066891:c4851739-4851497 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT185300 NZ_CP088134:2344318-2344605 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References