Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4135324..4135943 Replicon chromosome
Accession NZ_CP066891
Organism Klebsiella pneumoniae strain XHKP53

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JG783_RS20550 Protein ID WP_002892050.1
Coordinates 4135725..4135943 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JG783_RS20545 Protein ID WP_002892066.1
Coordinates 4135324..4135698 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG783_RS20535 4130476..4131669 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JG783_RS20540 4131692..4134838 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
JG783_RS20545 4135324..4135698 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JG783_RS20550 4135725..4135943 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JG783_RS20555 4136102..4136668 + 567 WP_002892030.1 maltose O-acetyltransferase -
JG783_RS20560 4136640..4136780 - 141 WP_004147370.1 hypothetical protein -
JG783_RS20565 4136801..4137271 + 471 WP_002892026.1 YlaC family protein -
JG783_RS20570 4137246..4138696 - 1451 Protein_4041 PLP-dependent aminotransferase family protein -
JG783_RS20575 4138797..4139495 + 699 WP_002892021.1 GNAT family protein -
JG783_RS20580 4139492..4139632 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JG783_RS20585 4139632..4139895 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185298 WP_002892050.1 NZ_CP066891:4135725-4135943 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185298 NZ_CP088134:c1531625-1531341 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT185298 WP_002892066.1 NZ_CP066891:4135324-4135698 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185298 NZ_CP088134:c1531857-1531615 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References